Silver-Catalyzed 7-exo-dig Cyclization of Silylenolether-ynesulfonamides
Dr. Clément F. Heinrich
Laboratoire de Chimie Organique Synthétique, Institut de Chimie, 1, rue Blaise Pascal, BP296/R8, 67008 Strasbourg, France
Search for more papers by this authorIndira Fabre
Département de Chimie, Ecole Normale Supérieure—PSL Research University, Sorbonne Universités—UPMC Univ Paris 06, CNRS UMR 8640 PASTEUR, 24, rue Lhomond, 75005 Paris, France
Search for more papers by this authorCorresponding Author
Dr. Laurence Miesch
Laboratoire de Chimie Organique Synthétique, Institut de Chimie, 1, rue Blaise Pascal, BP296/R8, 67008 Strasbourg, France
Search for more papers by this authorDr. Clément F. Heinrich
Laboratoire de Chimie Organique Synthétique, Institut de Chimie, 1, rue Blaise Pascal, BP296/R8, 67008 Strasbourg, France
Search for more papers by this authorIndira Fabre
Département de Chimie, Ecole Normale Supérieure—PSL Research University, Sorbonne Universités—UPMC Univ Paris 06, CNRS UMR 8640 PASTEUR, 24, rue Lhomond, 75005 Paris, France
Search for more papers by this authorCorresponding Author
Dr. Laurence Miesch
Laboratoire de Chimie Organique Synthétique, Institut de Chimie, 1, rue Blaise Pascal, BP296/R8, 67008 Strasbourg, France
Search for more papers by this authorGraphical Abstract
Dig this! Cyclization of silylenolether-ynesulfonamides proceeds at ambient temperature under mild reaction conditions under silver catalysis. Bridged compounds were obtained exclusively through 7-exo-dig reactions. The protocol is applicable to a wide range of substrates, thus leading to azabicyclic frameworks.
Abstract
Cyclization of silylenolether-ynesulfonamides proceeds at ambient temperature under mild reaction conditions under silver catalysis. Bridged compounds were obtained exclusively through 7-exo-dig reactions. The protocol is applicable to a wide range of substrates, thus leading to azabicyclic frameworks.
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