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Remote Stereocontrol Transmitted through Helicity^†

Dr. Craig P. Johnston

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://msmith.chem.ox.ac.uk

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Dr. Martin D. Smith,

Corresponding Author

Dr. Martin D. Smith

[email protected]

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://msmith.chem.ox.ac.uk

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://msmith.chem.ox.ac.uk===Search for more papers by this author

Dr. Craig P. Johnston,

Dr. Craig P. Johnston

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://msmith.chem.ox.ac.uk

Search for more papers by this author

Dr. Martin D. Smith,

Corresponding Author

Dr. Martin D. Smith

[email protected]

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://msmith.chem.ox.ac.uk

Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA (UK) http://msmith.chem.ox.ac.uk===Search for more papers by this author

First published: 26 February 2014

https://doi.org/10.1002/anie.201400154

Citations: 5

^†

We thank the European Research Council (grant agreement no. 259056 to M.D.S.) and EPSRC and Pfizer (industrial CASE award to C.P.J.).

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Graphical Abstract

Near…︁far…︁wherever you are! Two chiral residues at the N-terminus of a helical foldamer are sufficient to induce a significant helical screw-sense preference. The capacity of this helix to transmit stereochemical information is exemplified by highly stereoselective transformations conducted over nanometer distances.

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Volume53, Issue13

March 24, 2014

Pages 3315-3317

Remote Stereocontrol Transmitted through Helicity^†

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Remote Stereocontrol Transmitted through Helicity^†