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The Trifluoromethylating Sandmeyer Reaction: A Method for Transforming CN into CCF3†
†
D.L.B. gratefully acknowledges support from the EPSRC (award no. EP/K009494/1) and Prof. Steven V. Ley.
Graphical Abstract
A means to trifluoromethylate: The beneficial properties imparted by the trifluoromethylation of aromatic compounds continue to drive the discovery of novel reagents and reactions for the late-stage introduction of such moieties. Highlighted here is the recently discovered Sandmeyer trifluoromethylation approach, which now permits aromatic amines to be substrates in a direct trifluoromethylation strategy.
