Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures†
Corresponding Author
Prof. Dr. Bo Song
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Bo Song, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Xingyu Gao, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Fang Huang, Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorDipl. Qian Sun
Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorDr. Haikuo Li
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Search for more papers by this authorDr. Baosheng Ge
Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorDr. Ji Sheng Pan
Institute of Materials Research and Engineering, Singapore 117602 (Republic of Singapore)
Search for more papers by this authorProf. Dr. Andrew Thye Shen Wee
Physics Department, National University of Singapore, Singapore 117542 (Republic of Singapore)
Search for more papers by this authorDr. Yong Zhang
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China)
Search for more papers by this authorDr. Shaohua Huang
Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Search for more papers by this authorDr. Ruhong Zhou
IBM Thomas J. Watson Research Center, New York, NY 10598 (USA)
Search for more papers by this authorCorresponding Author
Xingyu Gao
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Bo Song, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Xingyu Gao, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Fang Huang, Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Fang Huang
Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Bo Song, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Xingyu Gao, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Fang Huang, Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorHaiping Fang
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Bo Song
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Bo Song, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Xingyu Gao, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Fang Huang, Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorDipl. Qian Sun
Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorDr. Haikuo Li
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Search for more papers by this authorDr. Baosheng Ge
Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorDr. Ji Sheng Pan
Institute of Materials Research and Engineering, Singapore 117602 (Republic of Singapore)
Search for more papers by this authorProf. Dr. Andrew Thye Shen Wee
Physics Department, National University of Singapore, Singapore 117542 (Republic of Singapore)
Search for more papers by this authorDr. Yong Zhang
College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China)
Search for more papers by this authorDr. Shaohua Huang
Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101 (China)
Search for more papers by this authorDr. Ruhong Zhou
IBM Thomas J. Watson Research Center, New York, NY 10598 (USA)
Search for more papers by this authorCorresponding Author
Xingyu Gao
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Bo Song, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Xingyu Gao, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Fang Huang, Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorCorresponding Author
Prof. Dr. Fang Huang
Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Bo Song, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Xingyu Gao, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Fang Huang, Center for Bioengineering and Biotechnology, China University of Petroleum (Huadong), Changjiang West Road 66, Qingdao 266580 (China)
Search for more papers by this authorHaiping Fang
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, P. O. Box 800-204, Shanghai 201800 (China)
Search for more papers by this authorWe thank Prof. Dr. W. Liu, H. Jiang, Y. Gao, and J. Gao for helpful discussions. This work was supported by the NSFC (11174310, 11290164, 21073236), NBRPC (2010CB934504), KIPCAS, NSFDYSSP (JQ201008), PNCETUMEC (NCET-10-0815), the Shanghai Supercomputer Center of China, and the Supercomputing Center of the Chinese Academy of Sciences.
Graphical Abstract
A good Al-rounder: Al ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. The rings are formed by the Al ion forming bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone, which destabilizes the protein and results in irreversible denaturation.
Abstract
A combination of ab initio calculations, circular dichroism, nuclear magnetic resonance, and X-ray photoelectron spectroscopy has shown that aluminum ions can induce the formation of backbone ring structures in a wide range of peptides, including neurodegenerative disease related motifs. These ring structures greatly destabilize the protein and result in irreversible denaturation. This behavior benefits from the ability of aluminum ions to form chemical bonds simultaneously with the amide nitrogen and carbonyl oxygen atoms on the peptide backbone.
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