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One Size Does Not Fit All—Bacterial Cell Death by Antibiotics Cannot Be Explained by the Action of Reactive Oxygen Species†
†
Jacobs University is acknowledged for funding.
Graphical Abstract
Back to square one: Two recent studies prove that reactive oxygen species (ROS) are not responsible for bacterial cell death after treatment with antibiotics. The ROS concept cannot be generalized to explain all processes resulting in cell death. The search for the mechanism of action of bacterial antibiotics must thus return to the beginning.
