Photochemical Steps in the Prebiotic Synthesis of Purine Precursors from HCN†
Eliot Boulanger
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany) http://www.sgk.mpg.de/private/barbatti
Search for more papers by this authorDr. Anakuthil Anoop
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302 (India)
Search for more papers by this authorDr. Dana Nachtigallova
Institute of Organic Chemistry and Biochemistry, AS CR, Flemingovo nam. 2, 166 10 Praha 6 (Czech Republic)
Search for more papers by this authorProf. Dr. Walter Thiel
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany) http://www.sgk.mpg.de/private/barbatti
Search for more papers by this authorCorresponding Author
Dr. Mario Barbatti
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany) http://www.sgk.mpg.de/private/barbatti
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany) http://www.sgk.mpg.de/private/barbattiSearch for more papers by this authorEliot Boulanger
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany) http://www.sgk.mpg.de/private/barbatti
Search for more papers by this authorDr. Anakuthil Anoop
Department of Chemistry, Indian Institute of Technology, Kharagpur 721302 (India)
Search for more papers by this authorDr. Dana Nachtigallova
Institute of Organic Chemistry and Biochemistry, AS CR, Flemingovo nam. 2, 166 10 Praha 6 (Czech Republic)
Search for more papers by this authorProf. Dr. Walter Thiel
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany) http://www.sgk.mpg.de/private/barbatti
Search for more papers by this authorCorresponding Author
Dr. Mario Barbatti
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany) http://www.sgk.mpg.de/private/barbatti
Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470 Mülheim an der Ruhr (Germany) http://www.sgk.mpg.de/private/barbattiSearch for more papers by this authorWe acknowledge fruitful discussions with Dr. M. Patil. The research at IOCB was part of the project RVO: 61388963.
Graphical Abstract
So much excitement: The mechanism for the photoconversion of the HCN tetramer into a precursor of purine nucleobases and nucleotides has been revealed by computational methods. Dissipation of the photoenergy in less than 2 ps eliminates the possibility of hot-ground-state reactions. Instead, a series of photoexcitations followed by internal conversion (IC) drives the reaction via an excited azetene (see picture).
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