The Fatty Acid Composition of Diacylglycerols Determines Local Signaling Patterns†
Dr. André Nadler
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
These authors contributed equally to this work.
Search for more papers by this authorDr. Gregor Reither
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
These authors contributed equally to this work.
Search for more papers by this authorSuihan Feng
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Search for more papers by this authorFrank Stein
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Search for more papers by this authorDr. Sabine Reither
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Search for more papers by this authorDr. Rainer Müller
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Search for more papers by this authorCorresponding Author
Priv.-Doz. Dr. Carsten Schultz
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)Search for more papers by this authorDr. André Nadler
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
These authors contributed equally to this work.
Search for more papers by this authorDr. Gregor Reither
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
These authors contributed equally to this work.
Search for more papers by this authorSuihan Feng
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Search for more papers by this authorFrank Stein
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Search for more papers by this authorDr. Sabine Reither
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Search for more papers by this authorDr. Rainer Müller
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Search for more papers by this authorCorresponding Author
Priv.-Doz. Dr. Carsten Schultz
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)
Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg (Germany)Search for more papers by this authorWe thank the Advanced Light Microscopy Facility (ALMF) of EMBL for expert support in microscopy. We acknowledge financial support by the DFG (Transregio 83).
Graphical Abstract
Caged compounds are designed to release biologically active signaling molecules with temporal, spatial, and even subcellular resolution. But how localized does the signal stay? Using the example of diacylglycerol, some signal responses (PKC) are shown to remain spatially distinct while other signals ([Ca2+]i) spread across the entire cell. Surprisingly, this distribution patterns depend on the fatty acid composition of the lipid species.
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