Multi-Chromatic pH-Activatable 19F-MRI Nanoprobes with Binary ON/OFF pH Transitions and Chemical-Shift Barcodes†
Dr. Xiaonan Huang
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Gang Huang
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Shanrong Zhang
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Koji Sagiyama
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Osamu Togao
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Xinpeng Ma
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Yiguang Wang
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorYang Li
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Todd C. Soesbe
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Baran D. Sumer
Department of Otolaryngology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorProf. Masaya Takahashi
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorProf. A. Dean Sherry
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorCorresponding Author
Prof. Jinming Gao
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)Search for more papers by this authorDr. Xiaonan Huang
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Gang Huang
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Shanrong Zhang
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Koji Sagiyama
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Osamu Togao
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Xinpeng Ma
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Yiguang Wang
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorYang Li
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Todd C. Soesbe
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorDr. Baran D. Sumer
Department of Otolaryngology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorProf. Masaya Takahashi
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorProf. A. Dean Sherry
Advance Imaging Research Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Search for more papers by this authorCorresponding Author
Prof. Jinming Gao
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Blvds, Dallas, TX 75390 (USA)Search for more papers by this authorThis work is supported by the NIH (R01CA129011, R01EB013149). We acknowledge the assistance of the Southwestern Small Animal Imaging Resource, which is supported in part by NCI U24 CA126608, the Simmons Cancer Center through an NCI Cancer Center Support Grant (P30 CA142543).
Graphical Abstract
Imaging all the people: Using ionizable diblock copolymers a series of nanoprobes encoded with different 19F reporters for specific pH transitions is prepared for use in MRI. The pH response of the nanoprobes is extremely sharp (ΔpHON/OFF≈0.25 pH), and results from the disassembly of polymer micelles (see scheme). A collection of three nanoprobes provides the proof of concept and allows for a qualitative measurement of environmental pH values.
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