Enantioselective Hydrogenation of α-Substituted Acrylic Acids Catalyzed by Iridium Complexes with Chiral Spiro Aminophosphine Ligands†
Prof. Shou-Fei Zhu
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
Search for more papers by this authorYan-Bo Yu
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
Search for more papers by this authorShen Li
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
Search for more papers by this authorLi-Xin Wang
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
Search for more papers by this authorCorresponding Author
Prof. Qi-Lin Zhou
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/Search for more papers by this authorProf. Shou-Fei Zhu
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
Search for more papers by this authorYan-Bo Yu
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
Search for more papers by this authorShen Li
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
Search for more papers by this authorLi-Xin Wang
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
Search for more papers by this authorCorresponding Author
Prof. Qi-Lin Zhou
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071 (China) http://zhou.nankai.edu.cn/Search for more papers by this authorWe thank the National Natural Science Foundation of China and the National Basic Research Program of China (2011CB808600, 2012CB821600), and the “111” project (B06005) of the Ministry of Education of China for financial support.
Graphical Abstract
Highly active: Iridium complexes with chiral spiro aminophosphine ligands were synthesized and applied as catalysts for the asymmetric hydrogenation of α-substituted acrylic acids (see scheme). The complexes were highly active catalysts, showing turnover frequencies of up to 6000 h−1, and catalyst loadings could be reduced to 0.01 mol %.
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