Effect of the Peptide Moiety of Lipid II on Bacterial Transglycosylase†
Hao-Wei Shih
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorYi-Fan Chang
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorWei-Jing Li
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorFan-Chun Meng
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorChia-Ying Huang
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorDr. Che Ma
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorDr. Ting-Jen R. Cheng
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorCorresponding Author
Prof. Dr. Chi-Huey Wong
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)Search for more papers by this authorCorresponding Author
Dr. Wei-Chieh Cheng
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)Search for more papers by this authorHao-Wei Shih
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorYi-Fan Chang
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorWei-Jing Li
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorFan-Chun Meng
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorChia-Ying Huang
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorDr. Che Ma
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorDr. Ting-Jen R. Cheng
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Search for more papers by this authorCorresponding Author
Prof. Dr. Chi-Huey Wong
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)Search for more papers by this authorCorresponding Author
Dr. Wei-Chieh Cheng
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)
Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Taipei 115 (Taiwan)Search for more papers by this authorThis work was supported by the National Science Council and Academia Sinica.
Graphical Abstract
The writing's on the (cell) wall: A series of Lipid II analogues with modifications to the peptide moiety were evaluated as substrates of bacterial transglycosylase. The first two positions on the peptide, D-lactate and L-alanine (see scheme), especially their methyl groups, were found to be essential for substrate-binding activity, an important discovery for the design of antibiotics to inhibit cell-wall biosynthesis.
Supporting Information
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