Conversion of Magnetic Impulses into Cellular Responses by Self-Assembled Nanoparticle–Vesicle Hydrogels†
Felicity de Cogan
School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
School of Materials, Materials Science Centre, The University of Manchester, Manchester, M13 9PL (UK)
Search for more papers by this authorAndrew Booth
School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
Search for more papers by this authorCorresponding Author
Dr. Julie E. Gough
School of Materials, Materials Science Centre, The University of Manchester, Manchester, M13 9PL (UK)
Julie E. Gough, School of Materials, Materials Science Centre, The University of Manchester, Manchester, M13 9PL (UK)
Simon J. Webb, School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
Search for more papers by this authorCorresponding Author
Dr. Simon J. Webb
School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
Julie E. Gough, School of Materials, Materials Science Centre, The University of Manchester, Manchester, M13 9PL (UK)
Simon J. Webb, School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
Search for more papers by this authorFelicity de Cogan
School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
School of Materials, Materials Science Centre, The University of Manchester, Manchester, M13 9PL (UK)
Search for more papers by this authorAndrew Booth
School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
Search for more papers by this authorCorresponding Author
Dr. Julie E. Gough
School of Materials, Materials Science Centre, The University of Manchester, Manchester, M13 9PL (UK)
Julie E. Gough, School of Materials, Materials Science Centre, The University of Manchester, Manchester, M13 9PL (UK)
Simon J. Webb, School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
Search for more papers by this authorCorresponding Author
Dr. Simon J. Webb
School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
Julie E. Gough, School of Materials, Materials Science Centre, The University of Manchester, Manchester, M13 9PL (UK)
Simon J. Webb, School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess St, Manchester M1 7DN (UK) http://www.webblab.org
Search for more papers by this authorThis work was supported by the award of a BBSRC Doctoral Training Grant to F.C. We thank Dr. R. Collins and Dr. A. Harvey for TEM, and Dr. L. Carney for cell culture.
Graphical Abstract
Crosslinking vesicles with magnetic nanoparticles produced MNPVs, self-assembled “nanopills” that can be “unlocked” by an alternating magnetic field (AMF), releasing chemical messengers stored within the vesicles. When MNPVs are co-immobilized with cells in a hydrogel matrix, exposure to an AMF magnetic signal releases the chemical messengers, which then induce a cellular response.
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