Multimodal Gadolinium-Enriched DNA–Gold Nanoparticle Conjugates for Cellular Imaging†
Ying Song
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
These authors contributed equally to this work.
Search for more papers by this authorXiaoyang Xu
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
These authors contributed equally to this work.
Search for more papers by this authorKeith W. MacRenaris
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
Search for more papers by this authorXue-Qing Zhang Dr.
Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 (USA)
Search for more papers by this authorChad A. Mirkin Prof.
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
Search for more papers by this authorThomas J. Meade Prof.
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
Search for more papers by this authorYing Song
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
These authors contributed equally to this work.
Search for more papers by this authorXiaoyang Xu
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
These authors contributed equally to this work.
Search for more papers by this authorKeith W. MacRenaris
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
Search for more papers by this authorXue-Qing Zhang Dr.
Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208 (USA)
Search for more papers by this authorChad A. Mirkin Prof.
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
Search for more papers by this authorThomas J. Meade Prof.
Department of Chemistry and International Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113 (USA), Fax: (1) 847-491-3832, Fax: (1) 847-467-5123
Search for more papers by this authorWe acknowledge financial support of the NCI/CCNE grant no. CA119341 and NIH grant no. R01EB005866. We thank E. Alex Waters for help with the 3T solution phantom images.
Graphical Abstract
Conjugate agent: A GdIII enriched DNA-AuNP conjugate for intracellular magnetic resonance and fluorescence imaging is reported. The agent exhibits high relaxivity per particle and high cell uptake properties that provide a means to image and map small cell populations.
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