Reversibly Stabilized Multifunctional Dextran Nanoparticles Efficiently Deliver Doxorubicin into the Nuclei of Cancer Cells†
Yu-Ling Li
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorLi Zhu
College of Pharmacy, Soochow University, Suzhou, 215123 (P.R. China)
Search for more papers by this authorZhaozhong Liu
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorRu Cheng Dr.
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorFenghua Meng Prof. Dr.
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorJing-Hao Cui Prof. Dr.
College of Pharmacy, Soochow University, Suzhou, 215123 (P.R. China)
Search for more papers by this authorShun-Jun Ji Prof. Dr.
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorZhiyuan Zhong Prof. Dr.
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorYu-Ling Li
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorLi Zhu
College of Pharmacy, Soochow University, Suzhou, 215123 (P.R. China)
Search for more papers by this authorZhaozhong Liu
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorRu Cheng Dr.
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorFenghua Meng Prof. Dr.
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorJing-Hao Cui Prof. Dr.
College of Pharmacy, Soochow University, Suzhou, 215123 (P.R. China)
Search for more papers by this authorShun-Jun Ji Prof. Dr.
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorZhiyuan Zhong Prof. Dr.
Biomedical Polymers Laboratory, and Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123 (P.R. China), Fax: (+86) 512-6588-0098 http://chemistry.suda.edu.cn/lab/swyygfz
Search for more papers by this authorThis work was financially supported by research grants from the National Natural Science Foundation of China (NSFC 50703028, 50973078, 20874070, and 20974073), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (08KJB150016), and the Program of Innovative Research Team of Soochow University.
Graphical Abstract
Getting in there: Efficient intracellular delivery of anticancer drugs is achieved by using reversibly cross-linked dextran nanoparticles, which are rapidly destabilized under reductive environments that mimic those of the intracellular compartments. These nanoparticles show high drug loading efficiency and reduction-triggered release of doxorubicin in vitro as well as inside tumor cells, particularly to the cell nucleus (see scheme).
Supporting Information
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