Volume 48, Issue 48 pp. 9171-9175
Communication

Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery

Zhihong Zhang Dr.

Zhihong Zhang Dr.

Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab

Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)

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Weiguo Cao Dr.

Weiguo Cao Dr.

Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab

Department of Chemistry, Shanghai University, Shanghai (China)

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Honglin Jin

Honglin Jin

Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab

Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)

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Jonathan F. Lovell

Jonathan F. Lovell

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5G 1L7 (Canada)

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Mi Yang Dr.

Mi Yang Dr.

Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab

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Lili Ding

Lili Ding

Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab

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Juan Chen Dr.

Juan Chen Dr.

Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab

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Ian Corbin Dr.

Ian Corbin Dr.

Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab

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Qingming Luo Dr.

Qingming Luo Dr.

Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)

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Gang Zheng Dr.

Gang Zheng Dr.

Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5G 1L7 (Canada)

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First published: 11 November 2009
Citations: 146

This study was conducted with the support of the Canadian Institute of Health Research, the Ontario Institute for Cancer Research through funding provided by the Government of Ontario, the Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research, and the Program for New Century Excellent Talents in University of China (NCET-08-0220, Z.H.Z.). We thank Dr. Monty Krieger of MIT for providing ldlA7 and ldlA(mSR-BI) cell lines.

Graphical Abstract

Getting straight to the point: A peptide–phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.