Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery†
Zhihong Zhang Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)
Search for more papers by this authorWeiguo Cao Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Department of Chemistry, Shanghai University, Shanghai (China)
Search for more papers by this authorHonglin Jin
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)
Search for more papers by this authorJonathan F. Lovell
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5G 1L7 (Canada)
Search for more papers by this authorMi Yang Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Search for more papers by this authorLili Ding
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Search for more papers by this authorJuan Chen Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Search for more papers by this authorIan Corbin Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Search for more papers by this authorQingming Luo Dr.
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)
Search for more papers by this authorGang Zheng Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5G 1L7 (Canada)
Search for more papers by this authorZhihong Zhang Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)
Search for more papers by this authorWeiguo Cao Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Department of Chemistry, Shanghai University, Shanghai (China)
Search for more papers by this authorHonglin Jin
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)
Search for more papers by this authorJonathan F. Lovell
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5G 1L7 (Canada)
Search for more papers by this authorMi Yang Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Search for more papers by this authorLili Ding
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Search for more papers by this authorJuan Chen Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Search for more papers by this authorIan Corbin Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Search for more papers by this authorQingming Luo Dr.
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan (China)
Search for more papers by this authorGang Zheng Dr.
Department of Medical Biophysics and Ontario Cancer Institute, University of Toronto, Toronto, Ontario M5G 1L7 (Canada) http://www.utoronto.ca/zhenglab
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario M5G 1L7 (Canada)
Search for more papers by this authorThis study was conducted with the support of the Canadian Institute of Health Research, the Ontario Institute for Cancer Research through funding provided by the Government of Ontario, the Joey and Toby Tanenbaum/Brazilian Ball Chair in Prostate Cancer Research, and the Program for New Century Excellent Talents in University of China (NCET-08-0220, Z.H.Z.). We thank Dr. Monty Krieger of MIT for providing ldlA7 and ldlA(mSR-BI) cell lines.
Graphical Abstract
Getting straight to the point: A peptide–phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).
Supporting Information
Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors.
Filename | Description |
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anie_200903112_sm_cytosolic_delivery.wmv2.1 MB | cytosolic_delivery |
anie_200903112_sm_miscellaneous_information.pdf515.7 KB | miscellaneous_information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1T. M. Allen, P. R. Cullis, Science 2004, 303, 1818.
- 2W. R. Sanhai, J. H. Sakamoto, R. Canady, M. Ferrari, Nat. Nanotechnol. 2008, 3, 242.
- 3K. A. Whitehead, R. Langer, D. G. Anderson, Nat. Rev. Drug Discovery 2009, 8, 129.
- 4D. Schweichel, J. Steitz, D. Tormo, E. Gaffal, A. Ferrer, S. Buchs, P. Speuser, A. Limmer, T. Tuting, J. Gene Med. 2006, 8, 1243.
- 5J. Panyam, V. Labhasetwar, Curr. Drug Delivery 2004, 1, 235.
- 6M. E. Davis, Z. G. Chen, D. M. Shin, Nat. Rev. Drug Discovery 2008, 7, 771.
- 7L. Zhang, F. X. Gu, J. M. Chan, A. Z. Wang, R. S. Langer, O. C. Farokhzad, Clin. Pharmacol. Ther. 2008, 83, 761.
- 8G. W. Gould, J. Lippincott-Schwartz, Nat. Rev. Mol. Cell Biol. 2009, 10, 287.
- 9J. Mercer, A. Helenius, Nat. Cell Biol. 2009, 11, 510.
- 10V. P. Torchilin, Pharm. Res. 2007, 24, 1.
- 11V. P. Torchilin, Nat. Rev. Drug Discovery 2005, 4, 145.
- 12R. Juliano, M. R. Alam, V. Dixit, H. Kang, Nucleic Acids Res. 2008, 36, 4158.
- 13M. V. Yezhelyev, L. Qi, R. M. O’Regan, S. Nie, X. Gao, J. Am. Chem. Soc. 2008, 130, 9006.
- 14H. Devalapally, D. Shenoy, S. Little, R. Langer, M. Amiji, Cancer Chemother. Pharmacol. 2007, 59, 477.
- 15Y. Hu, T. Litwin, A. R. Nagaraja, B. Kwong, J. Katz, N. Watson, D. J. Irvine, Nano Lett. 2007, 7, 3056.
- 16B. Y. Kim, W. Jiang, J. Oreopoulos, C. M. Yip, J. T. Rutka, W. C. Chan, Nano Lett. 2008, 8, 3887.
- 17K. C. Partlow, G. M. Lanza, S. A. Wickline, Biomaterials 2008, 29, 3367.
- 18A. M. Derfus, A. A. Chen, D. H. Min, E. Ruoslahti, S. N. Bhatia, Bioconjugate Chem. 2007, 18, 1391.
- 19J. K. Vasir, V. Labhasetwar, Adv. Drug Delivery Rev. 2007, 59, 718.
- 20S. Acton, A. Rigotti, K. T. Landschulz, S. Xu, H. H. Hobbs, M. Krieger, Science 1996, 271, 518.
- 21W. V. Rodrigueza, S. T. Thuahnai, R. E. Temel, S. Lund-Katz, M. C. Phillips, D. L. Williams, J. Biol. Chem. 1999, 274, 20344.
- 22I. R. Corbin, J. Chen, W. Cao, H. Li, S. Lund-Katz, G. Zheng, J. Biomed. Nanotechnol. 2007, 3, 367.
- 23M. Navab, G. M. Anantharamaiah, S. T. Reddy, A. M. Fogelman, Nat. Clin. Pract. Cardiovasc. Med. 2006, 3, 540.
- 24A. von Eckardstein, G. Castro, I. Wybranska, N. Theret, P. Duchateau, N. Duverger, J. C. Fruchart, G. Ailhaud, G. Assmann, J. Biol. Chem. 1993, 268, 2616.
- 25V. K. Mishra, M. N. Palgunachari, R. Krishna, J. Glushka, J. P. Segrest, G. M. Anantharamaiah, J. Biol. Chem. 2008, 283, 34393.
- 26D. L. Sparks, W. S. Davidson, S. Lund-Katz, M. C. Phillips, J. Biol. Chem. 1995, 270, 26910.
- 27R. A. Silva, R. Huang, J. Morris, J. Fang, E. O. Gracheva, G. Ren, A. Kontush, W. G. Jerome, K. A. Rye, W. S. Davidson, Proc. Natl. Acad. Sci. USA 2008, 105, 12176.
- 28M. Krieger, L. C. Smith, R. G. Anderson, J. L. Goldstein, Y. J. Kao, H. J. Pownall, A. M. Gotto, Jr., M. S. Brown, J. Supramol. Struct. 1979, 10, 467.
- 29A. Pluen, Y. Boucher, S. Ramanujan, T. D. McKee, T. Gohongi, E. di Tomaso, E. B. Brown, Y. Izumi, R. B. Campbell, D. A. Berk, R. K. Jain, Proc. Natl. Acad. Sci. USA 2001, 98, 4628.
- 30N. Tang, G. Du, N. Wang, C. Liu, H. Hang, W. Liang, J. Natl. Cancer Inst. 2007, 99, 1004.
- 31M. R. Dreher, W. Liu, C. R. Michelich, M. W. Dewhirst, F. Yuan, A. Chilkoti, J. Natl. Cancer Inst. 2006, 98, 335.
- 32S. D. Perrault, C. Walkey, T. Jennings, H. C. Fischer, W. C. W. Chan, Nano Lett. 2009, 9, 1909.
- 33M. Navab, S. Hama, G. Hough, A. M. Fogelman, Circulation 2003, 108, 1735.
- 34D. Duffy, D. J. Rader, Curr. Opin. Cardiol. 2005, 20, 301.
- 35S. Eisenberg, H. G. Windmueller, R. I. Levy, J. Lipid Res. 1973, 14, 446.
- 36S. M. Moghimi, A. C. Hunter, J. C. Murray, Pharmacol. Rev. 2001, 53, 283.