Review
25 Years after HIV Discovery: Prospects for Cure and Vaccine (Nobel Lecture)†
Luc Montagnier Prof.,
Luc Montagnier Prof.
World Foundation AIDS Research and Prevention, UNESCO, Paris (France)
Search for more papers by this authorLuc Montagnier Prof.,
Luc Montagnier Prof.
World Foundation AIDS Research and Prevention, UNESCO, Paris (France)
Search for more papers by this author†
Copyright© The Nobel Foundation 2008. We thank the Nobel Foundation, Stockholm, for permission to print this lecture.
Graphical Abstract
Viruses are the uniting theme of the 2008 Nobel Prize for Physiology or Medicine. Françoise Barré-Sinoussi and Luc Montagnier received their Prize for the discovery of the human immunodeficiency virus (HIV), and Harald zur Hausen identified that cervical cancer is triggered by papillomaviruses. The Nobel Laureates describe their research first-hand.
References
- 1“Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS)”: F. Barré-Sinoussi, J. C. Chermann, F. Rey, M. T. Nugeyre, S. Chamaret, J. Gruest, C. Dauguet, C. Axler-Blin, F. Vézinet-Brun, C. Rouzioux, W. Rozenbaum, L. Montagnier, Science 1983, 220, 868–871.
- 2“Detection of IgG antibodies to lymphadenopathy-associated virus in patients with AIDS or lymphadenopathy syndrome”: F. Brun-Vezinet, F. Barre-Sinoussi, A. G. Saimot, D. Christol, L. Montagnier, C. Rouzioux, D. Klatzmann, W. Rozenbaum, J. C. Gluckman, J. C. Chermann, Lancet 1984, 1253–1256.
- 3“Selective tropism of lymphadenopathy associated virus (LAV) for helper-inducer T lymphocytes”: D. Klatzmann, F. Barré-Sinoussi, M. T. Nugeyre, C. Dauguet, E. Vilmer, C. Griscelli, F. Brun-Vézinet, C. Rouzioux, J. C. Gluckman, J. C. Chermann, L. Montagnier, Science 1984, 225, 59–63.
- 4“Adaptation of Lymphadenopathy Associated Virus (LAV) to replication in EBV-transformed B lymphoblastoid cell lines”: L. Montagnier, J. Gruest, S. Chamaret, C. Dauguet, C. Axler, D. Guetard, M. T. Nugeyre, F. Barré-Sinoussi, J. C. Chermann, J. B. Brunet, D. Klatzmann, J. C. Gluckman, Science 1984, 225, 63–66.
- 5“LAV revisited: origins of the early HIV-1 isolates from Institut Pasteur”: S. Wain-Hobson, J. P. Vartanian, M. Henry, N. Chenciner, R. Cheynier, S. Delassus, L. Pedroza Martins, M. Sala, M. T. Nugeyre, D. Guetard, D. Klatzmann, J. C. Gluckman, W. Rozenbaum, F. Barré-Sinoussi, L. Montagnier, Science 1991, 252, 961–965.
- 6“A new human T-lymphotropic retrovirus: characterization and possible role in lymphadenopathy and acquired immune deficiency syndromes”: L. Montagnier, J. C. Chermann, F. Barré-Sinoussi, S. Chamaret, J. Gruest, M. T. Nugeyre, F. Rey, C. Dauguet, C. Axler-Blin, F. Vézinet-Brun, C. Rouzioux, G. A. Saimot, W. Rozenbaum, J. C. Gluckman, D. Klatzmann, E. Vilmer, C. Griscelli, C. Foyer-Gazengel, J. B. Brunet in Human T cell leukemia/lymphoma viruses (Eds.: ), Cold Spring Harbor Laboratory, New York, 1984, pp. 363–379.
- 7“Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS”: M. Popovic, M. G. Sarngadharan, E. Read, R. C. Gallo, Science 1984, 224, 497–500.
- 8“Isolation of lymphocytopathic retroviruses from San Francisco patients with AIDS”: J. A. Levy, A. D. Hoffman, S. M. Kramer, J. A. Lanois, J. M. Shimabukuro, L. S. Oskiro, Science 1984, 225, 840–842.
- 9“Molecular cloning of lymphadenopathy-associated virus”: M. Alizon, P. Sonigo, F. Barre-Sinoussi, J. C. Chermann, P. Tiollais, L. Montagnier, S. Wain-Hobson, Nature 1984, 312, 757–760.
- 10“Nucleotide sequence of AIDS virus, LAV”: S. Wain-Hobson, P. Sonigo, O. Danos, S. Cole, M. Alizon, Cell 1985, 40, 9–17.
- 11“Complete nucleotide sequence of the AIDS virus, HTLV-III”: L. Ratner, W. Haseltine, R. Patarca, K. J. Livak, B. Starcich, S. F. Josephs, E. R. Doran, A. Rafalski, E. A. Whitchorn, K. Baumeister, L. Ivanoff, S. R. Petteway, M. L. Pearson, J. A. Lautenbergen, T. S. Papas, J. Ghrayeb, N. T. Chang, R. C. Gallo, F. Wong-Staal, Nature 1985, 313, 277–284.
- 12“Isolation of a new human retrovirus from West African patients with AIDS”: F. Clavel, D. Guetard, F. Brun-Vézinet, S. Chamaret, M. A. Rey, M. O. Santos-Ferreira, A. G. Laurent, C. Daughet, C. Katlama, C. Rouzioux, D. Klatzmann, J. L. Champalimaud, L. Montagnier, Science 1986, 233, 343–346.
- 13“Transmissibility of human immunodeficiency virus in haemophilic and non-haemophilic children living in a private school in France”: A. Berthier, S. Chamaret, R. Fauchet, J. Fonlupt, N. Genetet, M. Gueguen, M. Pommereuil, A. Ruffault, L. Montagnier, Lancet 1986, 598–601.
- 14“Concorde: MCR/ANRS randomised double-blind controlled trial of immediate and deferred zidovudine in symptom-free HIV infection”: M. Seligmann, D. A. Warrel, J.-P. Aboulker, C. Carbon, J. H. Darbyshire, J. Dormont, E. Eschwege, D. J. Girling, D. R. James, J.-P. Levy, P. T. A. Peto, D. Schwarz, A. B. Stone, I. V. D. Weller, R. Withnall, K. Gelmon, E. Lafon, A. M. Swart, V. R. Aber, A. G. Babiker, S. Lhoro, A. J. Nunn, M. Vray, Lancet 1994, 343, 871–881.
- 15M. Zuniga, A. Whiteside, A. Ghaziani, J. G. Bartlett (Preface by L. Montagnier/R. Gallo R), A Decade of HAART. The Development and Global Impact of Highly Active Antiretroviral Therapy, Oxford University Press, Oxford, 2008.
- 16“Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein”: A. M. Sheehy, N. C. Gaddis, J. D. Choi, M. H. Malim, Nature 2002, 418, 646–650.
- 17“Mise en évidence d’un processus d’engagement vers la mort cellulaire par apoptose dans les lymphocytes de patients infectés par le VIH”: M. L. Gougeon, R. Olivier, S. Garcia, D. Guetard, T. Dragic, C. Dauguet, L. Montagnier, C. R. Acad. Sci. Ser. III 1991, 312, 529–537.
- 18“Programmed cell-death in AIDS-related HIV and SIV infections”: M. L. Gougeon, S. Garcia, J. Heeney, R. Tschopp, H. Lecoeur, D. Guetard, V. Rame, C. Dauguet, L. Montagnier, AIDS Res. Hum. Retroviruses 1993, 9, 553–563.
- 19“Programmed cell death in peripheral lymphocytes from HIV-infected persons: Increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression”: M. L. Gougeon, H. Lecoeur, A. Dulioust, M. G. Enouf, M. Crouvoisier, C. Goujard, T. Debord, L. Montagnier, J. Immunol. 1996, 156, 3509–3520.
- 20“Oxidative protein damage and degradation in lymphocytes from patients infected with human immunodeficiency virus”: G. Piedimonte, D. Guetard, M. Magnani, D. Corsi, I. Picerno, P. Spataro, L. Kramer, M. Montroni, G. Silvestri, J. F. Torres-Roca, L. Montagnier, J. Infect. Dis. 1997, 176, 655–664.
- 21“Increased plasma thiobarbituric acid-reactive substances (TBARS) before opportunistic infection symptoms in HIV-infected individuals”: O. Lopez, D. Bonnefont-Rousselot, M. Mollereau, R. Olivier, L. Montagnier, J. Emerit, M. Gentilini, J. Delattre, Clin. Chim. Acta 1996, 247, 181–187.
- 22“The human immunodeficiency virus-1 Tat protein increases cell proliferation, alters sensitivity to zinc chelator-induced apoptisis, and changes Sp1 DNA binding in HeLa cells”: M. Sevea, A. Faviera, M. Osmana, D. Hernandez, G. Vaitaitis, N. C. Flores, J. M. McCord, S. C. Flores, Arch. Biochem. Biophys. 1999, 361, 165–172.
- 23“In vitro influence of Mycoplasma penetrans on activation of peripheral T lymphocytes from healthy donors or human immunodeficiency virus-infected individuals”: Y. Sasaki, A. Blanchard, H. L. Watson, S. Garcia, A. Dulioust, L. Montagnier, M. L. Gougeon, Infect. Immun. 1995, 63, 4277–4283.
- 24“The challenge of finding a cure for HIV infection”: D. D. Richman, D. M. Margolis, M. Delaney, C. Warner Grenne, D. Hazuda, R. J. Pomerantz, Science 2009, 323, 1304–1307.
- 25“Toward functional eradication of HIV infection”: L. Montagnier, Future HIV Ther. 2007, 1, 3–4.
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