Communication

A Graphene Platform for Sensing Biomolecules^†

Chun-Hua Lu

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135

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Huang-Hao Yang Prof.,

Huang-Hao Yang Prof.

[email protected]

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135

The First Institute of Oceanography, SOA, Qingdao, 266061 (P.R. China)

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Chun-Ling Zhu Dr.,

Chun-Ling Zhu Dr.

The First Institute of Oceanography, SOA, Qingdao, 266061 (P.R. China)

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Xi Chen Prof.,

Xi Chen Prof.

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135

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Guo-Nan Chen Prof.,

Guo-Nan Chen Prof.

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135

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Chun-Hua Lu,

Chun-Hua Lu

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135

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Huang-Hao Yang Prof.,

Huang-Hao Yang Prof.

[email protected]

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135

The First Institute of Oceanography, SOA, Qingdao, 266061 (P.R. China)

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Chun-Ling Zhu Dr.,

Chun-Ling Zhu Dr.

The First Institute of Oceanography, SOA, Qingdao, 266061 (P.R. China)

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Xi Chen Prof.,

Xi Chen Prof.

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135

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Guo-Nan Chen Prof.,

Guo-Nan Chen Prof.

The Key Lab of Analysis and Detection Technology for Food Safety of the MOE, College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002 (China), Fax: (+86) 591-2286-6135

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First published: 09 June 2009

https://doi.org/10.1002/anie.200901479

Citations: 1,771

^†

This work was jointly supported by the National Natural Science Foundation of China (No. 20775019, No. 20735002) and the National Science and Technology Development Project (863 project No. 2006AA09Z168).

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Graphical Abstract

Sensitive platform: The use of graphene oxide (GO) as a platform for the sensitive and selective detection of DNA and proteins is presented. The interaction of GO and dye-labeled single-stranded DNA leads to quenching of the dye fluorescence. Conversely, the presence of a target DNA or protein leads to the binding of the dye-labeled DNA and target, releasing the DNA from GO, thereby restoring the dye fluorescence (see picture).

Abstract

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Volume48, Issue26

June 15, 2009

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A Graphene Platform for Sensing Biomolecules^†

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A Graphene Platform for Sensing Biomolecules^†