Multimodal Magnetic-Resonance/Optical-Imaging Contrast Agent Sensitive to NADH†
Chuqiao Tu
Department of Biomedical Engineering, University of California, Davis, 1 Shields Avenue, Davis, CA 95616 (USA), Fax: (+1) 530-754-5739
Search for more papers by this authorRyan Nagao
Department of Biomedical Engineering, University of California, Davis, 1 Shields Avenue, Davis, CA 95616 (USA), Fax: (+1) 530-754-5739
Search for more papers by this authorAngelique Y. Louie Prof.
Department of Biomedical Engineering, University of California, Davis, 1 Shields Avenue, Davis, CA 95616 (USA), Fax: (+1) 530-754-5739
Search for more papers by this authorChuqiao Tu
Department of Biomedical Engineering, University of California, Davis, 1 Shields Avenue, Davis, CA 95616 (USA), Fax: (+1) 530-754-5739
Search for more papers by this authorRyan Nagao
Department of Biomedical Engineering, University of California, Davis, 1 Shields Avenue, Davis, CA 95616 (USA), Fax: (+1) 530-754-5739
Search for more papers by this authorAngelique Y. Louie Prof.
Department of Biomedical Engineering, University of California, Davis, 1 Shields Avenue, Davis, CA 95616 (USA), Fax: (+1) 530-754-5739
Search for more papers by this authorThis research is supported by the National Institute of Health (RO3 EY13941-01) and NMR award of the University of California, Davis. We thank Dr. Benjamin R. Jarrett for help with cell experiments.
Graphical Abstract
Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.
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