Volume 48, Issue 22 pp. 3996-3998
Communication

Development of a Fluorescent Pb2+ Sensor

Lauren Marbella

Lauren Marbella

Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282 (USA), Fax: (+1) 412-396-5683, http://www.science.duq.edu/faculty/basu.html

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Barbara Serli-Mitasev Dr.

Barbara Serli-Mitasev Dr.

Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282 (USA), Fax: (+1) 412-396-5683, http://www.science.duq.edu/faculty/basu.html

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Partha Basu Dr.

Partha Basu Dr.

Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282 (USA), Fax: (+1) 412-396-5683, http://www.science.duq.edu/faculty/basu.html

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First published: 12 May 2009
Citations: 128

We thank the National Institutes of Health for partial financial support of this research. Lauren Marbella is a John V. Crable fellow. We thank Drs. Bernd Hammann, Mizanur Rahman, and Mitchell Johnson for experimental assistance and helpful discussions.

Graphical Abstract

A real turn-on: The emission intensity of heterocycle 1 increases upon binding to Pb2+. Thus, 1 acts as a small-molecule “turn-on” fluorescent sensor for lead. The sensor is highly selective and is functional over a wide range of pH values.

Abstract

A real turn-on: The emission intensity of heterocycle 1 increases upon binding to Pb2+. Thus, 1 acts as a small-molecule “turn-on” fluorescent sensor for lead. The sensor is highly selective and is functional over a wide range of pH values.

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