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Asymmetric Cross-Coupling of Non-Activated Secondary Alkyl Halides^†

Frank Glorius Prof. Dr.

[email protected]

Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster (Germany), Fax: (+49) 251-833-3202 http://www.uni-muenster.de/Chemie.oc/research/glorius/welcome.html

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Frank Glorius Prof. Dr.,

Frank Glorius Prof. Dr.

[email protected]

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First published: 15 October 2008

https://doi.org/10.1002/anie.200803509

Citations: 145

^†

I thank the Fonds der Chemischen Industrie, the Alfried Krupp von Bohlen und Halbach Foundation, and the Deutsche Forschungsgemeinschaft for generous financial support.

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Graphical Abstract

A new star is born: First reports on asymmetric cross-coupling reactions of racemic activated and non-activated secondary alkyl halides highlight the particular suitability of nickel catalysts for these reactions. Impressively high enantioselectivities were observed for Negishi, Hiyama, and Suzuki–Miyaura cross-coupling reactions (see scheme). The results can be expected to change retrosynthetic thinking.

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Volume47, Issue44

October 20, 2008

Pages 8347-8349

Asymmetric Cross-Coupling of Non-Activated Secondary Alkyl Halides^†

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Asymmetric Cross-Coupling of Non-Activated Secondary Alkyl Halides^†