Multifunctional Uniform Nanoparticles Composed of a Magnetite Nanocrystal Core and a Mesoporous Silica Shell for Magnetic Resonance and Fluorescence Imaging and for Drug Delivery†
Jaeyun Kim Dr.
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
These authors contributed equally to this work.
Search for more papers by this authorHoe Suk Kim Dr.
Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea), Fax: (+82) 2-743-6385
These authors contributed equally to this work.
Search for more papers by this authorNohyun Lee
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
Search for more papers by this authorTaeho Kim
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
Search for more papers by this authorHyoungsu Kim
Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea), Fax: (+82) 2-743-6385
Search for more papers by this authorTaekyung Yu Dr.
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
Search for more papers by this authorIn Chan Song Prof.
Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea), Fax: (+82) 2-743-6385
Search for more papers by this authorWoo Kyung Moon Prof.
Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea), Fax: (+82) 2-743-6385
Search for more papers by this authorTaeghwan Hyeon Prof.
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
Search for more papers by this authorJaeyun Kim Dr.
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
These authors contributed equally to this work.
Search for more papers by this authorHoe Suk Kim Dr.
Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea), Fax: (+82) 2-743-6385
These authors contributed equally to this work.
Search for more papers by this authorNohyun Lee
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
Search for more papers by this authorTaeho Kim
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
Search for more papers by this authorHyoungsu Kim
Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea), Fax: (+82) 2-743-6385
Search for more papers by this authorTaekyung Yu Dr.
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
Search for more papers by this authorIn Chan Song Prof.
Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea), Fax: (+82) 2-743-6385
Search for more papers by this authorWoo Kyung Moon Prof.
Diagnostic Radiology, Seoul National University Hospital and the Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul 110-744 (Korea), Fax: (+82) 2-743-6385
Search for more papers by this authorTaeghwan Hyeon Prof.
National Creative Research Initiative Center for Oxide Nanocrystalline Materials and School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744 (Korea), Fax: (+82) 2-886-8457
Search for more papers by this authorT.H. acknowledges financial support by the Korean Ministry of Education, Science and Technology through the National Creative Research Initiative Program of the Korea Science and Engineering Foundation (KOSEF). This study was supported in part by a grant from the Innovative Research Institute for Cell Therapy, Republic of Korea (A062260).
Graphical Abstract
Magnetic, fluorescent core–shell nanoparticles consist of a single Fe3O4 nanocrystal core and a dye-doped mesoporous silica shell with a poly(ethylene glycol) coating (see picture of TEM images and schematic depictions). These nanoparticles can be used as magnetic resonance and fluorescence imaging agents, and as drug delivery vehicles, thus making them novel candidates for simultaneous cancer diagnosis and therapy.
Supporting Information
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