Communication

Hierarchically Structured Microparticles Formed by Interfacial Instabilities of Emulsion Droplets Containing Amphiphilic Block Copolymers^†

Jintao Zhu Dr.

Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003, USA, Fax: (+1) 413-545-0082

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Ryan C. Hayward Prof.,

Ryan C. Hayward Prof.

[email protected]

Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003, USA, Fax: (+1) 413-545-0082

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Jintao Zhu Dr.,

Jintao Zhu Dr.

Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003, USA, Fax: (+1) 413-545-0082

Search for more papers by this author

Ryan C. Hayward Prof.,

Ryan C. Hayward Prof.

[email protected]

Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA 01003, USA, Fax: (+1) 413-545-0082

Search for more papers by this author

First published: 22 February 2008

https://doi.org/10.1002/anie.200704863

Citations: 115

^†

We gratefully acknowledge funding for this work provided by the National Science Foundation through grant CBET 0741885 and the MRSEC at UMass (DMR 0213695), and the Center for UMass-Industry Research on Polymers.

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Graphical Abstract

Blooming block copolymers! Uniform droplets of solvent that contain amphiphilic polystyrene–poly(ethylene oxide) diblock copolymers are prepared using a microcapillary device. Solvent removal drives interfacial instabilities, through which the polymer assembles into complex hierarchical microparticle structures (see picture).

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References

1I. Bala, S. Hariharan, M. Kumar, Crit. Rev. Ther. Drug Carrier Syst. 2004, 21, 387.
10.1615/CritRevTherDrugCarrierSyst.v21.i5.20
CAS PubMed Web of Science® Google Scholar
2S. Freitas, H. P. Merkle, B. Gander, J. Controlled Release 2005, 102, 313.
10.1016/j.jconrel.2004.10.015
CAS PubMed Web of Science® Google Scholar
3L. F. Zhang, A. Eisenberg, J. Am. Chem. Soc. 1996, 118, 3168.
10.1021/ja953709s
CAS Web of Science® Google Scholar
4Y. S. Yu, L. F. Zhang, A. Eisenberg, Macromolecules 1998, 31, 1144.
10.1021/ma971254g
CAS Web of Science® Google Scholar
5K. Yu, A. Eisenberg, Macromolecules 1998, 31, 3509.
10.1021/ma971419l
CAS Web of Science® Google Scholar
6N. S. Cameron, M. K. Corbierre, A. Eisenberg, Can. J. Chem. 1999, 77, 1311.
10.1139/v99-141
CAS Web of Science® Google Scholar
7S. C. Glotzer, M. J. Solomon, Nat. Mater. 2007, 6, 557.
10.1038/nmat1949
PubMed Web of Science® Google Scholar
8D. A. Edwards, J. Hanes, G. Caponetti, J. Hrkach, A. Ben-Jebria, M. L. Eskew, J. Mintzes, D. Deaver, N. Lotan, R. Langer, Science 1997, 276, 1868.
10.1126/science.276.5320.1868
CAS PubMed Web of Science® Google Scholar
9E. T. Kisak, B. Coldren, C. A. Evans, C. Boyer, J. A. Zasadzinski, Curr. Med. Chem. 2004, 11, 199.
10.2174/0929867043456197
CAS PubMed Web of Science® Google Scholar
10I. A. Okhapkin, E. E. Makhaeva, A. R. Khokhlov, Adv. Polym. Sci. 2006, 195, 177.
10.1007/12_051
CAS Web of Science® Google Scholar
11A. M. Gañán-Calvo, J. M. Gordillo, Phys. Rev. Lett. 2001, 87, 274501.
10.1103/PhysRevLett.87.274501
CAS PubMed Web of Science® Google Scholar
12S. L. Anna, N. Bontoux, H. A. Stone, Appl. Phys. Lett. 2003, 82, 364.
10.1063/1.1537519
CAS Web of Science® Google Scholar
13R. Granek, R. C. Ball, M. E. Cates, J. Phys. II 1993, 3, 829.
10.1051/jp2:1993170
CAS Web of Science® Google Scholar
14J. C. López-Montilla, P. E. Herrera-Morales, S. Pandey, D. O. Shah, J. Dispersion Sci. Technol. 2002, 23, 219.
10.1080/01932690208984202
CAS Web of Science® Google Scholar
15J. B. Jiao, E. J. Kramer, S. de Vos, M. Moller, C. Koning, Macromolecules 1999, 32, 6261.
10.1021/ma981262c
CAS Web of Science® Google Scholar
16J. B. Jiao, E. J. Kramer, S. de Vos, M. Moller, C. Koning, Polymer 1999, 40, 3585.
10.1016/S0032-3861(98)00565-5
CAS Web of Science® Google Scholar
17E. Girard-Reydet, J. P. Pascault, H. R. Brown, Macromolecules 2001, 34, 5349.
10.1021/ma002241x
CAS Web of Science® Google Scholar
18B. J. Kim, H. M. Kang, K. Char, K. Katsov, G. H. Fredrickson, E. J. Kramer, Macromolecules 2005, 38, 6106.
10.1021/ma047378s
CAS Web of Science® Google Scholar
19D. Volkmer, S. Tugulu, M. Fricke, T. Nielsen, Angew. Chem. 2003, 115, 60;
10.1002/ange.200390022
Google Scholar
Angew. Chem. Int. Ed. 2003, 42, 58.
10.1002/anie.200390051
PubMed Web of Science® Google Scholar
20H. G. Dobereiner, J. Kas, D. Noppl, I. Sprenger, E. Sackmann, Biophys. J. 1993, 65, 1396.
10.1016/S0006-3495(93)81203-7
CAS PubMed Web of Science® Google Scholar
21J. Kas, E. Sackmann, Biophys. J. 1991, 60, 825.
10.1016/S0006-3495(91)82117-8
CAS PubMed Web of Science® Google Scholar
22W. Wiese, W. Harbich, W. Helfrich, J. Phys. Condens. Matter 1992, 4, 1647.
10.1088/0953-8984/4/7/004
Web of Science® Google Scholar
23J. C. M. Lee, H. Bermudez, B. M. Discher, M. A. Sheehan, Y. Y. Won, F. S. Bates, D. E. Discher, Biotechnol. Bioeng. 2001, 73, 135.
10.1002/bit.1045
CAS PubMed Web of Science® Google Scholar

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Volume47, Issue11

February 28, 2008

Pages 2113-2116

Hierarchically Structured Microparticles Formed by Interfacial Instabilities of Emulsion Droplets Containing Amphiphilic Block Copolymers^†

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Hierarchically Structured Microparticles Formed by Interfacial Instabilities of Emulsion Droplets Containing Amphiphilic Block Copolymers†

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Hierarchically Structured Microparticles Formed by Interfacial Instabilities of Emulsion Droplets Containing Amphiphilic Block Copolymers^†