Volume 47, Issue 13 pp. 2470-2474
Communication

DNA Hydrogel Fiber with Self-Entanglement Prepared by Using an Ionic Liquid

Chang Kee Lee

Chang Kee Lee

Center for Bio-Artificial Muscle, Department of Biomedical Engineering, Hanyang University, Seoul, Korea, Fax: (+82) 2-2291-2320

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Su Ryon Shin

Su Ryon Shin

Center for Bio-Artificial Muscle, Department of Biomedical Engineering, Hanyang University, Seoul, Korea, Fax: (+82) 2-2291-2320

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Sun Hee Lee

Sun Hee Lee

Center for Bio-Artificial Muscle, Department of Biomedical Engineering, Hanyang University, Seoul, Korea, Fax: (+82) 2-2291-2320

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Ju-Hong Jeon Dr.

Ju-Hong Jeon Dr.

Department of Physiology, Seoul National University, Seoul, Korea

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Insuk So Dr.

Insuk So Dr.

Center for Bio-Artificial Muscle, Department of Biomedical Engineering, Hanyang University, Seoul, Korea, Fax: (+82) 2-2291-2320

Department of Physiology, Seoul National University, Seoul, Korea

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Tong Mook Kang Dr.

Tong Mook Kang Dr.

Department of Physiology, Sungkyunkwan University, Suwon, Korea

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Sun I. Kim Dr.

Sun I. Kim Dr.

Center for Bio-Artificial Muscle, Department of Biomedical Engineering, Hanyang University, Seoul, Korea, Fax: (+82) 2-2291-2320

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Ji Young Mun

Ji Young Mun

School of Life Sci. & Biotech. Korea University, Seoul, Korea

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Sung-Sik Han Dr.

Sung-Sik Han Dr.

School of Life Sci. & Biotech. Korea University, Seoul, Korea

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Geoffrey M. Spinks Dr.

Geoffrey M. Spinks Dr.

ARC Centre of Excellence for Electromaterials Science, University of Wollongong, NSW, Australia

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Gordon G. Wallace Dr.

Gordon G. Wallace Dr.

ARC Centre of Excellence for Electromaterials Science, University of Wollongong, NSW, Australia

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Seon Jeong Kim Dr.

Seon Jeong Kim Dr.

Center for Bio-Artificial Muscle, Department of Biomedical Engineering, Hanyang University, Seoul, Korea, Fax: (+82) 2-2291-2320

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First published: 10 March 2008
Citations: 52

This work was supported by the Creative Research Initiative Center for Bio-Artificial Muscle of the Ministry of Science & Technology (MOST) and the Korea Science and Engineering Foundation (KOSEF).

Graphical Abstract

Spinning strands: A hydrogel fiber made entirely of DNA without any covalent cross-links, composed of intertwined toroid entanglements of flexible DNA strands (see scheme), was prepared by a one-step wet-spinning method with a hydrophilic ionic liquid as the condensing agent and coagulation solvent. The internal structure of the fiber was a disordered arrangement of strands with a B-DNA form. The fiber was also stable in various aqueous solutions.

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