Volume 45, Issue 35 p. 5717

Cover Picture: Pd-Catalyzed α-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides: A Synergistic Effect of Two Metal Fluorides as Additives (Angew. Chem. Int. Ed. 35/2006)

Weiping Su Dr.

Weiping Su Dr.

Department of Chemistry, Gilman Hall, Iowa State University, Ames, IA 50011, USA, Fax: (+1) 515-294-0105

Current address: Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian 350002, P.R. China

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Steven Raders

Steven Raders

Department of Chemistry, Gilman Hall, Iowa State University, Ames, IA 50011, USA, Fax: (+1) 515-294-0105

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John G. Verkade Prof. Dr.

John G. Verkade Prof. Dr.

Department of Chemistry, Gilman Hall, Iowa State University, Ames, IA 50011, USA, Fax: (+1) 515-294-0105

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Xuebin Liao Dr.

Xuebin Liao Dr.

Department of Chemistry, Yale University, P.O. Box 208107, New Haven, CT 06520-8107, USA, Fax: (+1) 203-432-6144

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John F. Hartwig Prof. Dr.

John F. Hartwig Prof. Dr.

Department of Chemistry, Yale University, P.O. Box 208107, New Haven, CT 06520-8107, USA, Fax: (+1) 203-432-6144

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First published: 01 September 2006

Abstract

A synergistic combination of two metal fluoride additives is the key to the palladium-catalyzed coupling of aryl halides with silyl enol ethers. In their Communication on page 5852 ff., J. G. Verkade, J. F. Hartwig, and co-workers discuss the use of this approach to prepare α-aryl ketones from both cyclic and acyclic silyl enol ethers and a wide range of aryl bromides and chlorides. The cover picture depicts the difference in the yields from reactions with one and with two additives.

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