Cover Picture: Pd-Catalyzed α-Arylation of Trimethylsilyl Enol Ethers with Aryl Bromides and Chlorides: A Synergistic Effect of Two Metal Fluorides as Additives (Angew. Chem. Int. Ed. 35/2006)
Abstract
A synergistic combination of two metal fluoride additives is the key to the palladium-catalyzed coupling of aryl halides with silyl enol ethers. In their Communication on page 5852 ff., J. G. Verkade, J. F. Hartwig, and co-workers discuss the use of this approach to prepare α-aryl ketones from both cyclic and acyclic silyl enol ethers and a wide range of aryl bromides and chlorides. The cover picture depicts the difference in the yields from reactions with one and with two additives.