Highly Asymmetric Michael Addition to α,β-Unsaturated Ketones Catalyzed by 9-Amino-9-deoxyepiquinine†
Correction(s) for this article
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Highly Asymmetric Michael Addition to α,β-Unsaturated Ketones Catalyzed by 9-Amino-9-deoxyepiquinine
- Jian-Wu Xie,
- Wei Chen,
- Rui Li,
- Mi Zeng,
- Wei Du,
- Lei Yue,
- Ying-Chen Chen Prof. Dr.,
- Yong Wu Prof. Dr.,
- Jin Zhu Prof.,
- Jin-Gen Deng Prof. Dr.,
- Volume 46Issue 27Angewandte Chemie International Edition
- pages: 5049-5049
- First Published online: June 22, 2007
Jian-Wu Xie
Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, P.R. China, Fax: (+86) 28-852-239-78
Graduate School of the Chinese Academy of Sciences, Beijing, P.R. China
Search for more papers by this authorWei Chen
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorRui Li
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorMi Zeng
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorWei Du
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorLei Yue
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorYing-Chun Chen Prof. Dr.
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorYong Wu Prof. Dr.
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorJin Zhu Prof.
Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, P.R. China, Fax: (+86) 28-852-239-78
Search for more papers by this authorJin-Gen Deng Prof. Dr.
Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, P.R. China, Fax: (+86) 28-852-239-78
Search for more papers by this authorJian-Wu Xie
Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, P.R. China, Fax: (+86) 28-852-239-78
Graduate School of the Chinese Academy of Sciences, Beijing, P.R. China
Search for more papers by this authorWei Chen
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorRui Li
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorMi Zeng
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorWei Du
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorLei Yue
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorYing-Chun Chen Prof. Dr.
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorYong Wu Prof. Dr.
Key laboratory of Drug-Targeting of the Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, 610041, P.R. China, Fax: (+86) 28-85502609
Search for more papers by this authorJin Zhu Prof.
Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, P.R. China, Fax: (+86) 28-852-239-78
Search for more papers by this authorJin-Gen Deng Prof. Dr.
Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province, Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, P.R. China, Fax: (+86) 28-852-239-78
Search for more papers by this authorWe are grateful for the financial support of the National Natural Science Foundation of China (20502018), the Ministry of Education (NCET-05-0781), and Sichuan University.
Graphical Abstract
Michael–Michael–retro-Michael cascade reactions are promoted by the highly efficient organocatalyst 9-amino-9-deoxyepiquinine (1). The asymmetric direct vinylogous Michael addition of α,α-dicyanoalkenes to α,β-unsaturated ketones may be followed by an intramolecular Michael addition and a retro-Michael reaction to afford polysubstituted 2-cyclohexen-1-one derivatives with high enantioselectivity (see example).
Supporting Information
Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z603612_s.pdf or from the author.
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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