Metal–Organic Frameworks as Efficient Materials for Drug Delivery†
Patricia Horcajada
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: (+33) 139-254-358
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
Search for more papers by this authorChristian Serre
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: (+33) 139-254-358
Search for more papers by this authorMaría Vallet-Regí
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
Search for more papers by this authorMuriel Sebban
Tectospin group of Institut Lavoisier and NMRtec, Versailles, France
Search for more papers by this authorFrancis Taulelle
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: (+33) 139-254-358
Tectospin group of Institut Lavoisier and NMRtec, Versailles, France
Search for more papers by this authorGérard Férey
Institut Universitaire de France, Fax: (+33) 1-3925-4358
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: (+33) 139-254-358
Search for more papers by this authorPatricia Horcajada
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: (+33) 139-254-358
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
Search for more papers by this authorChristian Serre
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: (+33) 139-254-358
Search for more papers by this authorMaría Vallet-Regí
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Spain
Search for more papers by this authorMuriel Sebban
Tectospin group of Institut Lavoisier and NMRtec, Versailles, France
Search for more papers by this authorFrancis Taulelle
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: (+33) 139-254-358
Tectospin group of Institut Lavoisier and NMRtec, Versailles, France
Search for more papers by this authorGérard Férey
Institut Universitaire de France, Fax: (+33) 1-3925-4358
Institut Lavoisier, UMR CNRS 8180, Université de Versailles St-Quentin en Yvelines, 45 Avenue des Etats-Unis, 78035 Versailles Cedex, France, Fax: (+33) 139-254-358
Search for more papers by this authorThe authors are grateful to E. Fraga (C.A.I. of XRF spectroscopy, Complutense University) for collecting the X-ray fluorescence (XRF) spectra. Ibuprofen was kindly supplied by Laboratorios Dr. Esteve S.A.
Graphical Abstract
Fill 'em up: The metal carboxylates MIL-100 and MIL-101 act as porous matrices (see picture; MIL=Materials of Institut Lavoisier) for drug-delivery systems using Ibuprofen as a model substrate. Very large amounts of the drug could be incorporated, up to an unprecedented capacity of 1.4 g of drug per gram of porous solid for MIL-101, and the total release of Ibuprofen was achieved under physiological conditions in 3 (MIL-100) and 6 days (MIL-101).
Supporting Information
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