Volume 44, Issue 42 pp. 6938-6940

Communication

Solution-Phase Mixture Synthesis with Double-Separation Tagging: Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins^†

Craig S. Wilcox Prof. Dr.,

Craig S. Wilcox Prof. Dr.

[email protected]

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

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Venugopal Gudipati,

Venugopal Gudipati

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

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Hejun Lu,

Hejun Lu

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

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Serhan Turkyilmaz,

Serhan Turkyilmaz

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

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Dennis P. Curran Prof. Dr.,

Dennis P. Curran Prof. Dr.

[email protected]

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

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Craig S. Wilcox Prof. Dr.,

Craig S. Wilcox Prof. Dr.

[email protected]

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

Search for more papers by this author

Venugopal Gudipati,

Venugopal Gudipati

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

Search for more papers by this author

Hejun Lu,

Hejun Lu

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

Search for more papers by this author

Serhan Turkyilmaz,

Serhan Turkyilmaz

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

Search for more papers by this author

Dennis P. Curran Prof. Dr.,

Dennis P. Curran Prof. Dr.

[email protected]

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA, 15260, USA, Fax: (+1) 412-624-9861

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First published: 25 October 2005

https://doi.org/10.1002/anie.200501989

Citations: 24

^†

We thank the US National Institutes of Health for funding this work.

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Graphical Abstract

Two tags are better than one: Sixteen individual stereoisomers of murisolin (see scheme) are synthesized together and isolated in pure form with the aid of a double-separation tagging procedure. A strategy for solution-phase stereoisomer synthesis based on double-separation tagging and double demixing is implemented with fluoroalkyl and oligoethylene glycol (OEG, (OCH₂CH₂)_nOCH₃) tags.

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Volume44, Issue42

October 28, 2005

Pages 6938-6940

Solution-Phase Mixture Synthesis with Double-Separation Tagging: Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins^†

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Solution-Phase Mixture Synthesis with Double-Separation Tagging: Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins†

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Solution-Phase Mixture Synthesis with Double-Separation Tagging: Double Demixing of a Single Mixture Provides a Stereoisomer Library of 16 Individual Murisolins^†