Meteoritic Cα-Methylated α-Amino Acids and the Homochirality of Life: Searching for a Link
Marco Crisma Dr.
Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239
Search for more papers by this authorAlessandro Moretto Dr.
Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239
Search for more papers by this authorFernando Formaggio Prof.
Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239
Search for more papers by this authorBernard Kaptein Dr.
DSM Research, Life Sciences, Advanced Synthesis and Catalysis, P.O. Box 18, 6160 MD Geleen, The Netherlands
Search for more papers by this authorQuirinus B. Broxterman Dr.
DSM Research, Life Sciences, Advanced Synthesis and Catalysis, P.O. Box 18, 6160 MD Geleen, The Netherlands
Search for more papers by this authorClaudio Toniolo Prof.
Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239
Search for more papers by this authorMarco Crisma Dr.
Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239
Search for more papers by this authorAlessandro Moretto Dr.
Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239
Search for more papers by this authorFernando Formaggio Prof.
Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239
Search for more papers by this authorBernard Kaptein Dr.
DSM Research, Life Sciences, Advanced Synthesis and Catalysis, P.O. Box 18, 6160 MD Geleen, The Netherlands
Search for more papers by this authorQuirinus B. Broxterman Dr.
DSM Research, Life Sciences, Advanced Synthesis and Catalysis, P.O. Box 18, 6160 MD Geleen, The Netherlands
Search for more papers by this authorClaudio Toniolo Prof.
Institute of Biomolecular Chemistry, CNR and Department of Chemistry, University of Padova via Marzolo 1, 35131 Padova, Italy, Fax: (+39) 049-8275239
Search for more papers by this authorGraphical Abstract
Catch a falling star: Peptides from chiral, Cα-methylated α-amino acids (see scheme) found in L enantiomeric excess in meteorites show diastereoselectivity when reacting with racemic proteinogenic amino acids. Accordingly, the prebiotic soup of proteinogenic amino acids may have evolved into a chirally unbalanced system, eventually seeding the homochirality of life.
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