Thin-Chip Microspray System for High-Performance Fourier-Transform Ion-Cyclotron Resonance Mass Spectrometry of Biopolymers†
Joël S. Rossier Dr.
DiagnoSwiss S.A., Rte de L'Ile au bois 2 1870 Monthey, Switzerland
Search for more papers by this authorNikolay Youhnovski Dr.
University of Konstanz, Department of Chemistry Laboratory of Analytical Chemistry 78457 Konstanz, Germany, Fax: (+49) 7531-88-3097
Search for more papers by this authorNiels Lion Dipl.-Chem.
Laboratoire d'Éléctrochimie École Polytechnique Fédérale de Lausanne 1015 Lausanne, Switzerland
Search for more papers by this authorEugen Damoc Dipl.-Chem.
University of Konstanz, Department of Chemistry Laboratory of Analytical Chemistry 78457 Konstanz, Germany, Fax: (+49) 7531-88-3097
Search for more papers by this authorSusanne Becker Dipl.-Chem.
University of Konstanz, Department of Chemistry Laboratory of Analytical Chemistry 78457 Konstanz, Germany, Fax: (+49) 7531-88-3097
Search for more papers by this authorFrédéric Reymond Dr.
DiagnoSwiss S.A., Rte de L'Ile au bois 2 1870 Monthey, Switzerland
Search for more papers by this authorHubert H. Girault Prof. Dr.
Laboratoire d'Éléctrochimie École Polytechnique Fédérale de Lausanne 1015 Lausanne, Switzerland
Search for more papers by this authorMichael Przybylski Prof. Dr.
University of Konstanz, Department of Chemistry Laboratory of Analytical Chemistry 78457 Konstanz, Germany, Fax: (+49) 7531-88-3097
Search for more papers by this authorJoël S. Rossier Dr.
DiagnoSwiss S.A., Rte de L'Ile au bois 2 1870 Monthey, Switzerland
Search for more papers by this authorNikolay Youhnovski Dr.
University of Konstanz, Department of Chemistry Laboratory of Analytical Chemistry 78457 Konstanz, Germany, Fax: (+49) 7531-88-3097
Search for more papers by this authorNiels Lion Dipl.-Chem.
Laboratoire d'Éléctrochimie École Polytechnique Fédérale de Lausanne 1015 Lausanne, Switzerland
Search for more papers by this authorEugen Damoc Dipl.-Chem.
University of Konstanz, Department of Chemistry Laboratory of Analytical Chemistry 78457 Konstanz, Germany, Fax: (+49) 7531-88-3097
Search for more papers by this authorSusanne Becker Dipl.-Chem.
University of Konstanz, Department of Chemistry Laboratory of Analytical Chemistry 78457 Konstanz, Germany, Fax: (+49) 7531-88-3097
Search for more papers by this authorFrédéric Reymond Dr.
DiagnoSwiss S.A., Rte de L'Ile au bois 2 1870 Monthey, Switzerland
Search for more papers by this authorHubert H. Girault Prof. Dr.
Laboratoire d'Éléctrochimie École Polytechnique Fédérale de Lausanne 1015 Lausanne, Switzerland
Search for more papers by this authorMichael Przybylski Prof. Dr.
University of Konstanz, Department of Chemistry Laboratory of Analytical Chemistry 78457 Konstanz, Germany, Fax: (+49) 7531-88-3097
Search for more papers by this authorThis work was supported by the European Union, 5th Framework Research Programme QoL-2000, QLRT-2000-01903; Deutsche Forschungsgemeinschaft (Biopolymer Mass Spectrometry), Bonn (Germany), and the Office Fédéral de L'Éducation et de la Science (OFES grant No 01.0182).
Graphical Abstract
Microchip innovation: A thin-film microchip system has been developed for microelectrospray Fourier-transform ion-cyclotron resonance mass spectrometry. Application perspectives include the analysis of combinatorial libraries and high-performance proteomics (as shown for the peptide fragment of the phosphorylation domain (512–538) of human neurofibrillary tau protein; the seven phosphorylation sites are indicated in red).
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