Frontispiz: Discovery, Total Synthesis, and Anti-Inflammatory Evaluation of Naturally Occurring Naphthopyrone-Macrolide Hybrids as Potent NLRP3 Inflammasome Inhibitors
Dr. Chunxiao Sun
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
These authors contributed equally.
Search for more papers by this authorDr. Yuqi Jiang
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 China
Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong, 266071 China
These authors contributed equally.
Search for more papers by this authorChanglong Li
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
These authors contributed equally.
Search for more papers by this authorSimin Sun
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorJiaqi Lin
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorDr. Wenxue Wang
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorLuning Zhou
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorLiping Li
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorDr. Mudassir Shah
Department of Pharmacy, Abbottabad University of Science and Technology, Havellian, District, Abbottabad, 22010 KPK Pakistan
Search for more papers by this authorDr. Qian Che
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorDr. Guojian Zhang
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 China
Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong, 266071 China
Search for more papers by this authorDr. De Wang
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 China
Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong, 266071 China
Search for more papers by this authorDr. Tianjiao Zhu
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorCorresponding Author
Dr. Dehai Li
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 China
Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong, 266071 China
Search for more papers by this authorDr. Chunxiao Sun
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
These authors contributed equally.
Search for more papers by this authorDr. Yuqi Jiang
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 China
Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong, 266071 China
These authors contributed equally.
Search for more papers by this authorChanglong Li
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
These authors contributed equally.
Search for more papers by this authorSimin Sun
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorJiaqi Lin
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorDr. Wenxue Wang
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorLuning Zhou
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorLiping Li
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorDr. Mudassir Shah
Department of Pharmacy, Abbottabad University of Science and Technology, Havellian, District, Abbottabad, 22010 KPK Pakistan
Search for more papers by this authorDr. Qian Che
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorDr. Guojian Zhang
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 China
Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong, 266071 China
Search for more papers by this authorDr. De Wang
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 China
Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong, 266071 China
Search for more papers by this authorDr. Tianjiao Zhu
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Search for more papers by this authorCorresponding Author
Dr. Dehai Li
Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266100 China
Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, 266237 China
Marine Biomedical Research Institute of Qingdao, Qingdao, Shandong, 266071 China
Search for more papers by this authorGraphical Abstract
Natural Products. The NLRP3 inflammasome plays a crucial role in regulating the innate immune system and inflammatory signaling. In their Research Article (e202405860), Dehai Li and co-workers report that a naphthopyrone-macrolide hybrid derived from Antarctic fungus serves as a potent NLRP3 inflammasome inhibitor.
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