Strong Protein Adhesives through Lanthanide-enhanced Structure Folding and Stack Density
Dr. Jing Chen
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Weiwei Shi
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Yubin Ren
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
Search for more papers by this authorDr. Kelu Zhao
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorDr. Yangyi Liu
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorBo Jia
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorLai Zhao
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorMing Li
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorDr. Yawei Liu
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorDr. Juanjuan Su
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorDr. Chao Ma
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
Search for more papers by this authorDr. Fan Wang
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorDr. Jing Sun
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241 China
Search for more papers by this authorProf. Dr. Yang Tian
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241 China
Search for more papers by this authorCorresponding Author
Dr. Jingjing Li
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorProf. Dr. Hongjie Zhang
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Xiangfu Laboratory, Jiaxing, 314102 China
Search for more papers by this authorProf. Dr. Kai Liu
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Xiangfu Laboratory, Jiaxing, 314102 China
Search for more papers by this authorDr. Jing Chen
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, 130012 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Weiwei Shi
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
These authors contributed equally to this work.
Search for more papers by this authorDr. Yubin Ren
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
Search for more papers by this authorDr. Kelu Zhao
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorDr. Yangyi Liu
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorBo Jia
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorLai Zhao
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorMing Li
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorDr. Yawei Liu
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorDr. Juanjuan Su
College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorDr. Chao Ma
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
Search for more papers by this authorDr. Fan Wang
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorDr. Jing Sun
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241 China
Search for more papers by this authorProf. Dr. Yang Tian
School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241 China
Search for more papers by this authorCorresponding Author
Dr. Jingjing Li
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Search for more papers by this authorProf. Dr. Hongjie Zhang
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Xiangfu Laboratory, Jiaxing, 314102 China
Search for more papers by this authorProf. Dr. Kai Liu
Engineering Research Center of Advanced Rare Earth Materials, Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084 China
State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 China
Xiangfu Laboratory, Jiaxing, 314102 China
Search for more papers by this authorAbstract
Generating strong adhesion by engineered proteins has the potential for high technical applications. Current studies of adhesive proteins are primarily limited to marine organisms, e.g., mussel adhesive proteins. Here, we present a modular engineering strategy to generate a type of exotic protein adhesives with super strong adhesion behaviors. In the protein complexes, the lanmodulin (LanM) underwent α-helical conformational transition induced by lanthanides, thereby enhancing the stacking density and molecular interactions of adhesive protein. The resulting adhesives exhibited outstanding lap-shear strength of ≈31.7 MPa, surpassing many supramolecular and polymer adhesives. The extreme temperature (−196 to 200 °C) resistance capacity and underwater adhesion performance can significantly broaden their practical application scenarios. Ex vivo and in vivo experiments further demonstrated the persistent adhesion performance for surgical sealing and healing applications.
Conflict of interest
The authors declare no conflict of interest.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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