A Water-Stable and Red-Emissive Radical Cation for Mutp53 Cancer Therapy
Zikai Zhou
National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, School of Biomedical Science and Engineering, School of Medicine, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006 China
These authors contributed equally to this work.
Search for more papers by this authorJieying Qian
National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, School of Biomedical Science and Engineering, School of Medicine, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006 China
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Kai Liu
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, 530200 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Yunjiao Zhang
National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, School of Biomedical Science and Engineering, School of Medicine, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Meng Gao
National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, School of Biomedical Science and Engineering, School of Medicine, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Ben Zhong Tang
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172 China
Search for more papers by this authorZikai Zhou
National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, School of Biomedical Science and Engineering, School of Medicine, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006 China
These authors contributed equally to this work.
Search for more papers by this authorJieying Qian
National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, School of Biomedical Science and Engineering, School of Medicine, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006 China
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Kai Liu
Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning, 530200 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Yunjiao Zhang
National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, School of Biomedical Science and Engineering, School of Medicine, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Meng Gao
National Engineering Research Center for Tissue Restoration and Reconstruction, Key Laboratory of Biomedical Engineering of Guangdong Province, Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education, Innovation Center for Tissue Restoration and Reconstruction, School of Biomedical Science and Engineering, School of Medicine, School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510006 China
Search for more papers by this authorCorresponding Author
Prof. Dr. Ben Zhong Tang
School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172 China
Search for more papers by this authorAbstract
Compared with conventional closed-shell fluorophores, radical cations provide an opportunity for development of red-to-NIR fluorophores with small sizes and easy preparation. However, most radical cations reported in the literature suffer from poor stability in water solution and are almost non-emissive. To tackle this challenge, we herein develop a deep-red-emissive and water-stable pyrrole radical cation P⋅+−DPA−Zn, which can be easily generated from P−DPA−Zn by air oxidation. The deep-red-emissive P⋅+−DPA−Zn can be used for imaging-guided mitochondria-targeted delivery of Zn2+ into cancer cells to promote mutant p53 proteins degradation and abrogate mutp53-manifested gain of function, including reduced chemotherapy resistance, inhibited cancer cell migration, decreased tumor cell colony and sphere formation. The water-stable and deep-red emissive pyrrole radical cation is thus promising for cancer theranostic applications.
Open Research
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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