Engineering Multifunctional DNA Hybrid Nanospheres through Coordination-Driven Self-Assembly
Dr. Mengyuan Li
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 China
These authors contributed equally to this work.
Search for more papers by this authorCongli Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
These authors contributed equally to this work.
Search for more papers by this authorZhenghan Di
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
These authors contributed equally to this work.
Search for more papers by this authorHui Li
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115 USA
Search for more papers by this authorJingfang Zhang
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
Search for more papers by this authorWenting Xue
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
Search for more papers by this authorProf. Meiping Zhao
College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 China
Search for more papers by this authorProf. Ke Zhang
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115 USA
Search for more papers by this authorProf. Yuliang Zhao
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorCorresponding Author
Prof. Lele Li
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorDr. Mengyuan Li
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 China
These authors contributed equally to this work.
Search for more papers by this authorCongli Wang
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
These authors contributed equally to this work.
Search for more papers by this authorZhenghan Di
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
These authors contributed equally to this work.
Search for more papers by this authorHui Li
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115 USA
Search for more papers by this authorJingfang Zhang
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
Search for more papers by this authorWenting Xue
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
Search for more papers by this authorProf. Meiping Zhao
College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871 China
Search for more papers by this authorProf. Ke Zhang
Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, 02115 USA
Search for more papers by this authorProf. Yuliang Zhao
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorCorresponding Author
Prof. Lele Li
CAS Key Laboratory for Biomedical Effects of Nanomaterials, and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190 China
University of Chinese Academy of Sciences, Beijing, 100049 China
Search for more papers by this authorAbstract
Developing simple and general approaches for the synthesis of nanometer-sized DNA materials with specific morphologies and functionalities is important for various applications. Herein, a novel approach for the synthesis of a new set of DNA-based nanoarchitectures through coordination-driven self-assembly of FeII ions and DNA molecules is reported. By fine-tuning the assembly, Fe–DNA nanospheres of precise sizes and controlled compositions can be produced. The hybrid nanoparticles can be tailored for delivery of functional DNA to cells in vitro and in vivo with enhanced biological function. This highlights the potential of metal ion coordination as a tool for directing the assembly of DNA architectures, which conceptualizes a new pathway to expand the repertoire of DNA-based nanomaterials. This methodology will advance both the fields of DNA nanobiotechnology and metal–ligand coordination chemistry.
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