Magnetocatalytic Graphene Quantum Dots Janus Micromotors for Bacterial Endotoxin Detection
Corresponding Author
Dr. Beatriz Jurado-Sánchez
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Madrid, Spain
These authors contributed equally.
Search for more papers by this authorMarta Pacheco
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Madrid, Spain
These authors contributed equally.
Search for more papers by this authorJaime Rojo
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Madrid, Spain
These authors contributed equally.
Search for more papers by this authorCorresponding Author
Prof. Alberto Escarpa
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Madrid, Spain
Search for more papers by this authorCorresponding Author
Dr. Beatriz Jurado-Sánchez
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Madrid, Spain
These authors contributed equally.
Search for more papers by this authorMarta Pacheco
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Madrid, Spain
These authors contributed equally.
Search for more papers by this authorJaime Rojo
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Madrid, Spain
These authors contributed equally.
Search for more papers by this authorCorresponding Author
Prof. Alberto Escarpa
Department of Analytical Chemistry, Physical Chemistry and Chemical Engineering, University of Alcalá, Madrid, Spain
Search for more papers by this authorAbstract
Magnetocatalytic hybrid Janus micromotors encapsulating phenylboronic acid (PABA) modified graphene quantum dots (GQDs) are described herein as ultrafast sensors for the detection of deadly bacteria endotoxins. A bottom-up approach was adopted to synthesize an oil-in-water emulsion containing the GQDs along with a high loading of platinum and iron oxide nanoparticles on one side of the Janus micromotor body. The two different “active regions” enable highly efficient propulsion in the presence of hydrogen peroxide or magnetic actuation without the addition of a chemical fuel. Fluorescence quenching was observed upon the interaction of GQDs with the target endotoxin (LPS), whereby the PABA tags acted as highly specific recognition receptors of the LPS core polysaccharide region. Such adaptive hybrid operation and highly specific detection hold considerable promise for diverse clinical, agrofood, and biological applications and integration in future lab-on-chip technology.
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