Ligand-Promoted Borylation of C(sp3)H Bonds with Palladium(II) Catalysts
Jian He
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorHeng Jiang
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorRyosuke Takise
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorRu-Yi Zhu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Gang Chen
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorProf. Dr. Hui-Xiong Dai
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. T. G. Murali Dhar
Discovery Chemistry, Bristol-Myers Squibb Company, Route 206 and Provinceline Road, Princeton, NJ 08543 (USA)
Search for more papers by this authorDr. Jun Shi
Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA)
Search for more papers by this authorDr. Hao Zhang
Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA)
Search for more papers by this authorDr. Peter T. W. Cheng
Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Jin-Quan Yu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)Search for more papers by this authorJian He
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorHeng Jiang
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorRyosuke Takise
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorRu-Yi Zhu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. Gang Chen
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorProf. Dr. Hui-Xiong Dai
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Search for more papers by this authorDr. T. G. Murali Dhar
Discovery Chemistry, Bristol-Myers Squibb Company, Route 206 and Provinceline Road, Princeton, NJ 08543 (USA)
Search for more papers by this authorDr. Jun Shi
Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA)
Search for more papers by this authorDr. Hao Zhang
Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA)
Search for more papers by this authorDr. Peter T. W. Cheng
Discovery Chemistry, Bristol-Myers Squibb Company, 311 Pennington Rocky Hill Road, Pennington, NJ 08534 (USA)
Search for more papers by this authorCorresponding Author
Prof. Dr. Jin-Quan Yu
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)
Department of Chemistry, The Scripps Research Institute (TSRI), 10550 North Torrey Pines Road, La Jolla, CA 92037 (USA)Search for more papers by this authorAbstract
A quinoline-based ligand effectively promotes the palladium-catalyzed borylation of C(sp3)H bonds. Primary β-C(sp3)H bonds in carboxylic acid derivatives as well as secondary C(sp3)H bonds in a variety of carbocyclic rings, including cyclopropanes, cyclobutanes, cyclopentanes, cyclohexanes, and cycloheptanes, can thus be borylated. This directed borylation method complements existing iridium(I)- and rhodium(I)-catalyzed CH borylation reactions in terms of scope and operational conditions.
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