Fluorescence Imaging In Vivo at Wavelengths beyond 1500 nm
Shuo Diao
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
These authors contribute to the work equally.
Search for more papers by this authorDr. Jeffrey L. Blackburn
Chemical and Materials Science Center, National Renewable Energy Laboratory, Golden, Colorado 80401 (USA)
These authors contribute to the work equally.
Search for more papers by this authorDr. Guosong Hong
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
These authors contribute to the work equally.
Search for more papers by this authorAlexander L. Antaris
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorDr. Junlei Chang
Division of Hematology, School of Medicine, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorDr. Justin Z. Wu
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorBo Zhang
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorDr. Kai Cheng
Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorProf. Calvin J. Kuo
Division of Hematology, School of Medicine, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorCorresponding Author
Prof. Hongjie Dai
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)Search for more papers by this authorShuo Diao
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
These authors contribute to the work equally.
Search for more papers by this authorDr. Jeffrey L. Blackburn
Chemical and Materials Science Center, National Renewable Energy Laboratory, Golden, Colorado 80401 (USA)
These authors contribute to the work equally.
Search for more papers by this authorDr. Guosong Hong
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
These authors contribute to the work equally.
Search for more papers by this authorAlexander L. Antaris
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorDr. Junlei Chang
Division of Hematology, School of Medicine, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorDr. Justin Z. Wu
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorBo Zhang
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorDr. Kai Cheng
Department of Radiology and Bio-X Program, School of Medicine, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorProf. Calvin J. Kuo
Division of Hematology, School of Medicine, Stanford University, Stanford, California 94305 (USA)
Search for more papers by this authorCorresponding Author
Prof. Hongjie Dai
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)
Department of Chemistry, Stanford University, Stanford, California 94305 (USA)Search for more papers by this authorAbstract
Compared to imaging in the visible and near-infrared regions below 900 nm, imaging in the second near-infrared window (NIR-II, 1000–1700 nm) is a promising method for deep-tissue high-resolution optical imaging in vivo mainly owing to the reduced scattering of photons traversing through biological tissues. Herein, semiconducting single-walled carbon nanotubes with large diameters were used for in vivo fluorescence imaging in the long-wavelength NIR region (1500–1700 nm, NIR-IIb). With this imaging agent, 3–4 μm wide capillary blood vessels at a depth of about 3 mm could be resolved. Meanwhile, the blood-flow speeds in multiple individual vessels could be mapped simultaneously. Furthermore, NIR-IIb tumor imaging of a live mouse was explored. NIR-IIb imaging can be generalized to a wide range of fluorophores emitting at up to 1700 nm for high-performance in vivo optical imaging.
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References
- 1
- 1aJ. V. Frangioni, Curr. Opin. Chem. Biol. 2003, 7, 626;
- 1bS. A. Hilderbrand, R. Weissleder, Curr. Opin. Chem. Biol. 2010, 14, 71;
- 1cX. Le Guével, C. Spies, N. Daum, G. Jung, M. Schneider, Nano Res. 2012, 5, 379;
- 1dT. Yang, Q. Liu, S. Pu, Z. Dong, C. Huang, F. Li, Nano Res. 2012, 5, 494.
- 2
- 2aS. Diao, G. Hong, J. T. Robinson, L. Jiao, A. L. Antaris, J. Z. Wu, C. L. Choi, H. Dai, J. Am. Chem. Soc. 2012, 134, 16971;
- 2bG. Hong, S. Diao, J. Chang, A. L. Antaris, C. Chen, B. Zhang, S. Zhao, D. N. Atochin, P. L. Huang, K. I. Andreasson, Nat. Photonics 2014, 8, 723;
- 2cG. Hong, J. C. Lee, J. T. Robinson, U. Raaz, L. Xie, N. F. Huang, J. P. Cooke, H. Dai, Nat. Med. 2012, 18, 1841;
- 2dG. Hong, Y. Zou, A. L. Antaris, S. Diao, D. Wu, K. Cheng, X. Zhang, C. Chen, B. Liu, Y. He, Nat. Commun. 2014, 5, 4206;
- 2eD. Naczynski, M. Tan, M. Zevon, B. Wall, J. Kohl, A. Kulesa, S. Chen, C. Roth, R. Riman, P. Moghe, Nat. Commun. 2013, 4, 2199;
- 2fA. M. Smith, M. C. Mancini, S. Nie, Nat. Nanotechnol. 2009, 4, 710;
- 2gK. Welsher, Z. Liu, S. P. Sherlock, J. T. Robinson, Z. Chen, D. Daranciang, H. Dai, Nat. Nanotechnol. 2009, 4, 773;
- 2hH. Yi, D. Ghosh, M.-H. Ham, J. Qi, P. W. Barone, M. S. Strano, A. M. Belcher, Nano Lett. 2012, 12, 1176.
- 3
- 3aK. Welsher, S. P. Sherlock, H. J. Dai, Proc. Natl. Acad. Sci. USA 2011, 108, 8943;
- 3bJ. T. Robinson, G. Hong, Y. Liang, B. Zhang, O. K. Yaghi, H. Dai, J. Am. Chem. Soc. 2012, 134, 10664;
- 3cG. Hong, J. C. Lee, A. Jha, S. Diao, K. H. Nakayama, L. Hou, T. C. Doyle, J. T. Robinson, A. L. Antaris, H. Dai, Circ.: Cardiovasc. Imaging 2014, 7, 517.
- 4
- 4aT. Guo, P. Nikolaev, A. Thess, D. Colbert, R. Smalley, Chem. Phys. Lett. 1995, 243, 49;
- 4bS. M. Bachilo, M. S. Strano, C. Kittrell, R. H. Hauge, R. E. Smalley, R. B. Weisman, Science 2002, 298, 2361;
- 4cM. J. O’Connell, S. M. Bachilo, C. B. Huffman, V. C. Moore, M. S. Strano, E. H. Haroz, K. L. Rialon, P. J. Boul, W. H. Noon, C. Kittrell, J. Ma, R. H. Hauge, R. B. Weisman, R. E. Smalley, Science 2002, 297, 593.
- 5A. Bashkatov, E. Genina, V. Kochubey, V. Tuchin, J. Phys. D 2005, 38, 2543.
- 6K. S. Mistry, B. A. Larsen, J. L. Blackburn, ACS Nano 2013, 7, 2231.
- 7Y. Miyata, K. Shiozawa, Y. Asada, Y. Ohno, R. Kitaura, T. Mizutani, H. Shinohara, Nano Res. 2011, 4, 963.
- 8Princeton Instruments, 2D-OMA V InGaAs camera user manual.
- 9
- 9aJ. W. Xuan, M. Bygrave, H. Jiang, F. Valiyeva, J. Dunmore-Buyze, D. W. Holdsworth, J. I. Izawa, G. Bauman, M. Moussa, S. F. Winter, Cancer Res. 2007, 67, 2830;
- 9bK. Z. Abd-Elmoniem, A. Youssef, Y. M. Kadah, Biomed. Eng. IEEE Trans. 2002, 49, 997.
- 10E. M. Hillman, A. Moore, Nat. Photonics 2007, 1, 526.
- 11Z. Liu, C. Davis, W. Cai, L. He, X. Chen, H. Dai, Proc. Natl. Acad. Sci. USA 2008, 105, 1410.
- 12A. K. Iyer, G. Khaled, J. Fang, H. Maeda, Drug Discovery Today 2006, 11, 812.
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