Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter†
Correction(s) for this article
-
Berichtigung: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter
- Andreas Brust,
- Ching-I. A. Wang,
- Norelle L. Daly,
- Joe Kennerly,
- Mahsa Sadeghi,
- Macdonald J. Christie,
- Richard J. Lewis,
- Mehdi Mobli,
- Paul F. Alewood,
- Volume 130Issue 19Angewandte Chemie
- pages: 5299-5299
- First Published online: April 27, 2018
Corresponding Author
Dr. Andreas Brust
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Andreas Brust, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Mehdi Mobli, Centre for Advanced Imaging, The University of Queensland, St Lucia 4072 QLD (Australia)
Paul F. Alewood, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorDr. Ching-I. A. Wang
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorProf. Norelle L. Daly
Norelle Daly Centre for Biodiscovery and Molecular Development of Therapeutics, School of Pharmacy and Molecular Sciences, James Cook University, Cairns (Australia)
Search for more papers by this authorJoe Kennerly
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorMahsa Sadeghi
Discipline of Pharmacology, University of Sydney (Australia)
Search for more papers by this authorProf. Macdonald J. Christie
Discipline of Pharmacology, University of Sydney (Australia)
Search for more papers by this authorProf. Richard J. Lewis
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorCorresponding Author
Dr. Mehdi Mobli
Centre for Advanced Imaging, The University of Queensland, St Lucia 4072 QLD (Australia)
Andreas Brust, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Mehdi Mobli, Centre for Advanced Imaging, The University of Queensland, St Lucia 4072 QLD (Australia)
Paul F. Alewood, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorCorresponding Author
Prof. Paul F. Alewood
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Andreas Brust, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Mehdi Mobli, Centre for Advanced Imaging, The University of Queensland, St Lucia 4072 QLD (Australia)
Paul F. Alewood, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorCorresponding Author
Dr. Andreas Brust
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Andreas Brust, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Mehdi Mobli, Centre for Advanced Imaging, The University of Queensland, St Lucia 4072 QLD (Australia)
Paul F. Alewood, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorDr. Ching-I. A. Wang
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorProf. Norelle L. Daly
Norelle Daly Centre for Biodiscovery and Molecular Development of Therapeutics, School of Pharmacy and Molecular Sciences, James Cook University, Cairns (Australia)
Search for more papers by this authorJoe Kennerly
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorMahsa Sadeghi
Discipline of Pharmacology, University of Sydney (Australia)
Search for more papers by this authorProf. Macdonald J. Christie
Discipline of Pharmacology, University of Sydney (Australia)
Search for more papers by this authorProf. Richard J. Lewis
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorCorresponding Author
Dr. Mehdi Mobli
Centre for Advanced Imaging, The University of Queensland, St Lucia 4072 QLD (Australia)
Andreas Brust, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Mehdi Mobli, Centre for Advanced Imaging, The University of Queensland, St Lucia 4072 QLD (Australia)
Paul F. Alewood, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorCorresponding Author
Prof. Paul F. Alewood
Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Andreas Brust, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Mehdi Mobli, Centre for Advanced Imaging, The University of Queensland, St Lucia 4072 QLD (Australia)
Paul F. Alewood, Institute of Molecular Bioscience, The University of Queensland, St Lucia QLD 4072 (Australia)
Search for more papers by this authorWe acknowledge financial support by NHMRC (Program Grant No. 351446).
Graphical Abstract
Peptid mit Schleifchen: Peptidschleifen-Mimetika des klinisch relevanten Norepinephrin-Wiederaufnahmehemmers wurden mithilfe einer Hochdurchsatz-Synthese entwickelt, bei der Peptidthioester zunächst erzeugt und anschließend unter nativer chemischer Ligation cyclisiert werden. Die abgebildeten cyclischen Disulfid-Peptidmimetika sind in Struktur und Funktion dem Stammpeptid sehr ähnlich, aber deutlich stoffwechselbeständiger.
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