Impact of Strand Length on the Stability of Parallel-β-Sheet Secondary Structure†
Dr. Felix Freire
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
These authors contributed equally to this work.
Search for more papers by this authorAaron M. Almeida
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
These authors contributed equally to this work.
Search for more papers by this authorDr. John D. Fisk
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
Search for more papers by this authorJay D. Steinkruger
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
Search for more papers by this authorCorresponding Author
Prof. Samuel H. Gellman
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)Search for more papers by this authorDr. Felix Freire
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
These authors contributed equally to this work.
Search for more papers by this authorAaron M. Almeida
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
These authors contributed equally to this work.
Search for more papers by this authorDr. John D. Fisk
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
Search for more papers by this authorJay D. Steinkruger
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
Search for more papers by this authorCorresponding Author
Prof. Samuel H. Gellman
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)
Department of Chemistry, University of Wisconsin–Madison, 1101 University Av., Madison, WI 53726 (USA)Search for more papers by this authorThis research was supported by the NIH (GM-061238). F.F. was supported in part by an MEC-Fulbright Postdoctoral Fellowship. J.D.F. was supported in part by a biophysics training grant from NIGMS. NMR spectrometers were purchased with partial support from NIH and NSF.
Graphical Abstract
Molekulares Design kann für die Untersuchung genutzt werden, ob die Sekundärstruktur von parallelen β-Faltblättern einer längenabhängigen kooperativen Stabilisierung entlang der Strangausrichtung unterliegt (siehe Bild). Die Stabilität von parallelen β-Faltblättern wird durch die Verlängerung der Stränge durch Einführung von geeigneten Resten (B) stetig erhöht, während die Einführung von anderen Resten (A) diese Stabilisierung aufhebt.
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