Modular Polymer-Caged Nanobins as a Theranostic Platform with Enhanced Magnetic Resonance Relaxivity and pH-Responsive Drug Release†
Dr. Sang-Min Lee
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
These authors contributed equally to this work.
Search for more papers by this authorDr. Ying Song
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
These authors contributed equally to this work.
Search for more papers by this authorDr. Bong Jin Hong
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
These authors contributed equally to this work.
Search for more papers by this authorDr. Keith W. MacRenaris
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
These authors contributed equally to this work.
Search for more papers by this authorDaniel J. Mastarone
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
Search for more papers by this authorProf. Thomas V. O'Halloran
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
Search for more papers by this authorCorresponding Author
Prof. Thomas J. Meade
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713Search for more papers by this authorCorresponding Author
Prof. SonBinh T. Nguyen
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713Search for more papers by this authorDr. Sang-Min Lee
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
These authors contributed equally to this work.
Search for more papers by this authorDr. Ying Song
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
These authors contributed equally to this work.
Search for more papers by this authorDr. Bong Jin Hong
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
These authors contributed equally to this work.
Search for more papers by this authorDr. Keith W. MacRenaris
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
These authors contributed equally to this work.
Search for more papers by this authorDaniel J. Mastarone
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
Search for more papers by this authorProf. Thomas V. O'Halloran
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
Search for more papers by this authorCorresponding Author
Prof. Thomas J. Meade
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713Search for more papers by this authorCorresponding Author
Prof. SonBinh T. Nguyen
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713
Department of Chemistry and the Center of Cancer Nanotechnology Excellence, Northwestern University, 2145 Sheridan Rd. Evanston, IL 60208-3113 (USA), Fax: (+1) 847-491-7713Search for more papers by this authorThis work is financially supported by the NIH (NCI Center of Cancer Nanotechnology Excellence Grant U54 A119341 and Core Grant P30 A060553 to the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and award number R01EB005866 from the National Institutes of Biomedical Imaging and Bioengineering). B.J.H. is partially supported by the National Research Foundation of Korea (NRF-2009-352-C00088).
Graphical Abstract
Polymerverkapselte Nanobehälter (PCNs), die zu Kupfer(I)-katalysierten Klick-Reaktionen fähig sind, ermöglichen die Kombination von Gadolinium(III)-Kontrastmitteln für die Kernspintomographie mit dem Cytostatikum Gemcitabin (GMC) in einer theranostischen Plattform (siehe Bild). Die mit Gadolinium(III) verknüpften und mit GMC beladenen PCNs (GdIII–PCNGMC) zeigen deutlich verbesserte Ergebnisse bezüglich der r1-Relaxivitäten, der Wirkstoffaufnahme und der pH-empfindlichen Wirkstoff-Freisetzung.
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