Gold-Nanoparticle-Based Multicolor Nanobeacons for Sequence-Specific DNA Analysis†
Shiping Song Prof.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorZhiqiang Liang Dr.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorJuan Zhang
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorLihua Wang Dr.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorGenxi Li Prof.
Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093 (China)
Search for more papers by this authorChunhai Fan Prof.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorShiping Song Prof.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorZhiqiang Liang Dr.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorJuan Zhang
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorLihua Wang Dr.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorGenxi Li Prof.
Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093 (China)
Search for more papers by this authorChunhai Fan Prof.
Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800 (China), Fax: (+86) 21-5955-6902
Search for more papers by this authorThis work was supported by the National Natural Science Foundation (20725516, 20873175, 60537030), Ministry of Science and Technology (2006CB933000, 2007CB936000, 2007AA06A406), Ministry of Health (2009ZX10004-301), and Shanghai Municipal Commission for Science and Technology (0952nm04600, 08jc1422600).
Graphical Abstract
Jetzt auch in Farbe: Mehrfarbige molekulare Beacons wurden durch Konjugation von Stamm-Schleife-Sonden und Helfer-Oligonucleotiden an große Gold-Nanopartikel erzeugt. Die Nanobeacons reagieren auf die Hybridisierung mit komplementären DNA-Strängen durch eine mehrfarbige Emission und können DNA-Analyte parallel differenzieren (siehe Bild).
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