A Highly Stereoselective Hydrogen-Bond-Mediated Michael–Michael Cascade Process through Dynamic Kinetic Resolution†
Jian Wang Dr.
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorHexin Xie
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorHao Li Dr.
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorLiansuo Zu
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorWei Wang Prof. Dr.
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorJian Wang Dr.
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorHexin Xie
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorHao Li Dr.
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorLiansuo Zu
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorWei Wang Prof. Dr.
Department of Chemistry & Chemical Biology, University of New Mexico, MSC03 2060, Albuquerque, NM 87131-0001, USA, Fax: (+1) 505-277-2609
Search for more papers by this authorFinancial support of this research was provided by the NSF (CHE-0704015) and the ACS Petroleum Research Fund.
Graphical Abstract
Michael macht's möglich: Die Titelreaktion, die direkt zu Thiochromanen führt, wird effizient durch ein Thioharnstoffderivat eines China-Alkaloids katalysiert. Das organokatalytische Verfahren umfasst eine neuartige dynamische Racematspaltung durch eine Kaskade aus Michael- und Retro-Michael-Reaktionen.
Supporting Information
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