Development and Biological Assessment of Fully Water-Soluble Helical Aromatic Amide Foldamers†
Elizabeth R. Gillies Dr.
Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215
Current address: Departments of Chemistry and Chemical and Biochemical Engineering, The University of Western Ontario, London N6A 5B7, Canada
Search for more papers by this authorFrédérique Deiss
Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215
Search for more papers by this authorCathy Staedel Dr.
Université Bordeaux Victor Segalen 2, INSERM U869, 146 rue Léo Saignat, 33076 Bordeaux, France
Search for more papers by this authorJean-Marie Schmitter Prof.
Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215
Search for more papers by this authorIvan Huc Dr.
Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215
Search for more papers by this authorElizabeth R. Gillies Dr.
Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215
Current address: Departments of Chemistry and Chemical and Biochemical Engineering, The University of Western Ontario, London N6A 5B7, Canada
Search for more papers by this authorFrédérique Deiss
Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215
Search for more papers by this authorCathy Staedel Dr.
Université Bordeaux Victor Segalen 2, INSERM U869, 146 rue Léo Saignat, 33076 Bordeaux, France
Search for more papers by this authorJean-Marie Schmitter Prof.
Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215
Search for more papers by this authorIvan Huc Dr.
Université Bordeaux 1 – CNRS UMR5248, Institut Européen de Chimie et Biologie, 2 rue Robert Escarpit, 33607 Pessac, France, Fax: (+33) 540-002-215
Search for more papers by this authorThis work was supported by the European Commission (Marie Curie Postdoctoral Fellowship to E.R.G.) and by the Conseil Régional d'Aquitaine. We thank Katell Bathany for mass spectroscopy data.
Graphical Abstract
Nicht biologisch, aber biologisch aktiv: Helicale Arylamid-Oligomere, die sich in ihren Strukturen deutlich von den α-Peptiden, β-Peptiden und Peptoiden unterscheiden, sind dennoch vergleichbar gut zellgängig, kaum toxisch und überdies absolut beständig gegen Zersetzung durch Proteasen. TFA−=Trifluoracetat.
Supporting Information
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