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Aufbau quartärer Stereozentren: neue Möglichkeiten durch enantioselektive Michael-Reaktion
Jens Christoffers Prof. Dr.,
Angelika Baro Dr.,
Jens Christoffers Prof. Dr.
Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Deutschland, Fax: (+49) 711-685-4269
Search for more papers by this authorAngelika Baro Dr.
Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Deutschland, Fax: (+49) 711-685-4269
Search for more papers by this authorJens Christoffers Prof. Dr.,
Angelika Baro Dr.,
Jens Christoffers Prof. Dr.
Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Deutschland, Fax: (+49) 711-685-4269
Search for more papers by this authorAngelika Baro Dr.
Institut für Organische Chemie, Universität Stuttgart, Pfaffenwaldring 55, 70569 Stuttgart, Deutschland, Fax: (+49) 711-685-4269
Search for more papers by this authorGraphical Abstract
Durch PdII katalysierte Michael-Reaktionen zwischen β-Dicarbonylen 1 und Enonen 2 können quartäre Stereozentren (gelb unterlegt) mit Selektivitäten von 90 % ee bei relativ hohen Temperaturen (−10 °C) aufgebaut werden. Damit ist ein Durchbruch bei der enantioselektiven Synthese gelungen.
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