Sinus Microbial Communities in Patients With Chronic Rhinosinusitis Are Unpredictable Over Time
Tary Yin
Department of Otorhinolaryngology, Auckland City Hospital, Auckland, New Zealand
Department of Surgery, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorBrett Wagner Mackenzie
Department of Surgery, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorFiona Radcliff
Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorDavid Broderick
Department of Surgery, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorKristi Biswas
Department of Surgery, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorCorresponding Author
Richard Douglas
Department of Otorhinolaryngology, Auckland City Hospital, Auckland, New Zealand
Department of Surgery, The University of Auckland, Auckland, New Zealand
Correspondence: Richard Douglas ([email protected])
Search for more papers by this authorTary Yin
Department of Otorhinolaryngology, Auckland City Hospital, Auckland, New Zealand
Department of Surgery, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorBrett Wagner Mackenzie
Department of Surgery, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorFiona Radcliff
Department of Molecular Medicine and Pathology, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorDavid Broderick
Department of Surgery, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorKristi Biswas
Department of Surgery, The University of Auckland, Auckland, New Zealand
Search for more papers by this authorCorresponding Author
Richard Douglas
Department of Otorhinolaryngology, Auckland City Hospital, Auckland, New Zealand
Department of Surgery, The University of Auckland, Auckland, New Zealand
Correspondence: Richard Douglas ([email protected])
Search for more papers by this authorFunding: The Passe & Williams Foundation.

Conflicts of Interest
The authors declare no conflicts of interest.
Supporting Information
Filename | Description |
---|---|
alr23506-sup-0001-SuppMat.docx10.8 MB | Supporting Information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
References
- 1B. Wagner Mackenzie, D. W. Waite, M. Hoggard, R. G. Douglas, M. W. Taylor, and K. Biswas, “Bacterial Community Collapse: A Meta-Analysis of the Sinonasal Microbiota in Chronic Rhinosinusitis,” Environmental Microbiology 19, no. 1 (2017): 381–392.
- 2E. J. Cleland, A. Bassiouni, S. Vreugde, and P.-J. Wormald, “The Bacterial Microbiome in Chronic Rhinosinusitis: Richness, Diversity, Postoperative Changes, and Patient Outcomes,” American Journal of Rhinology & Allergy 30, no. 1 (2016): 37–43.
- 3L. J. Hauser, D. Ir, T. T. Kingdom, C. E. Robertson, D. N. Frank, and V. R. Ramakrishnan, “Investigation of Bacterial Repopulation After Sinus Surgery and Perioperative Antibiotics,” International Forum of Allergy & Rhinology 6, no. 1 (2016): 34–40.
- 4B. Wagner Mackenzie, K. Chang, M. Zoing, et al., “Longitudinal Study of the Bacterial and Fungal Microbiota in the Human Sinuses Reveals Seasonal and Annual Changes in Diversity,” Scientific Reports 9, no. 1 (2019): 1–10.
- 5I. F. Escapa, T. Chen, Y. Huang, P. Gajare, F. E. Dewhirst, and K. P. Lemon, “New Insights Into Human Nostril Microbiome From the Expanded Human Oral Microbiome Database (eHOMD): A Resource for the Microbiome of the Human Aerodigestive Tract,” Msystems 3, no. 6 (2018): e00187–00118.
- 6 R Core Team. R: A Language and Environmental for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2017.
- 7J. M. Challis, M. S. Baptista, R. Ragupathy, C. K.-W. Lee, and A. J. Wood, “A Pilot Randomised Controlled Trial of Oral Doxycycline After Endoscopic Sinus Surgery and its Effects on the Sinonasal Microbiome,” Rhinology Online 5 (2022): 49–61.
10.4193/RHINOL/22.004 Google Scholar
- 8L. M. Cherian, A. Bassiouni, C. M. Cooksley, S. Vreugde, P.-J. Wormald, and A. J Psaltis. The Clinical Outcomes of Medical Therapies in Chronic Rhinosinusitis is Independent of Microbiomic Outcomes: A Double-Blinded, Randomised Placebo-Controlled Trial. Rhinology 2020; 58(6): 559–567.
- 9J. Siu, B. W. Mackenzie, L. Klingler, et al., “Sinonasal and Gastrointestinal Bacterial Composition and Abundance are Stable After 1 Week of Once-Daily Oral Antibiotic Treatment for Chronic Rhinosinusitis,” International Forum of Allergy & Rhinology 11, no. 9 (2021): 1355–1366.
- 10Q. S. Huang, N. Turner, T. Wood, et al., “Impact of the COVID-19 Related Border Restrictions on Influenza and Other Common respiratory Viral Infections in New Zealand,” Influenza and Other Respiratory Viruses 18, no. 2 (2024): e13247.