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Brachmann-de Lange syndrome with normal IQ

Corresponding Author

Howard M. Saal M.D.

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

Department of Medical Genetics, Children's National Medical Center, 111 Michigan Avenue, N.W., Washington, DC 20010Search for more papers by this author

Carole A. Samango-Sprouse,

Carole A. Samango-Sprouse

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

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Leslie A. Rodnan,

Leslie A. Rodnan

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

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Kenneth N. Rosenbaum,

Kenneth N. Rosenbaum

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

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Deborah A. Custer,

Deborah A. Custer

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

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Howard M. Saal M.D.,

Corresponding Author

Howard M. Saal M.D.

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

Department of Medical Genetics, Children's National Medical Center, 111 Michigan Avenue, N.W., Washington, DC 20010Search for more papers by this author

Carole A. Samango-Sprouse,

Carole A. Samango-Sprouse

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

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Leslie A. Rodnan,

Leslie A. Rodnan

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

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Kenneth N. Rosenbaum,

Kenneth N. Rosenbaum

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

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Deborah A. Custer,

Deborah A. Custer

Department of Medical Genetics, Children's National Medical Center, and the Department of Pediatrics, The George Washington School of Medicine, Washington, District of Columbia

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First published: 15 November 1993

https://doi.org/10.1002/ajmg.1320470711

Citations: 8

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Abstract

The Brachmann-de Lange syndrome is a disorder with a high degree of clinical variability, generally associated with moderate to severe mental retardation. To date, 7 previous cases of Brachmann-de Lange syndrome with normal intelligence (IQ > 70) have been described. We report the eighth case of Brachmann-de Lange syndrome with normal intelligence. In reviewing thr literature, consistent clinical menifestations seen in these 8 patients that are of prognostic value are the absence of significant limb anomalies and birth weight > 2,500 g. © 1993 Wiley-Liss, Inc.

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Volume47, Issue7

15 November 1993

Pages 995-998

Brachmann-de Lange syndrome with normal IQ

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Brachmann-de Lange syndrome with normal IQ

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