Research Article

High-sensitivity CRP: Possible link between job stress and atherosclerosis

Corresponding Author

Weixian Xu MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

Correspondence to: Weixian Xu, MD, Department of Cardiology, Peking University Third Hospital, No 49 North Garden Road, Haidian District, Beijing 100191, China, E-mail: [email protected]

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Baoxia Chen MD,

Baoxia Chen MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Lijun Guo MD,

Lijun Guo MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Zhaoping Li MD,

Zhaoping Li MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Yiming Zhao PhD,

Yiming Zhao PhD

Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, China

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Hui Zeng MD,

Hui Zeng MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Weixian Xu MD,

Corresponding Author

Weixian Xu MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

Correspondence to: Weixian Xu, MD, Department of Cardiology, Peking University Third Hospital, No 49 North Garden Road, Haidian District, Beijing 100191, China, E-mail: [email protected]

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Baoxia Chen MD,

Baoxia Chen MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Lijun Guo MD,

Lijun Guo MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Zhaoping Li MD,

Zhaoping Li MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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Yiming Zhao PhD,

Yiming Zhao PhD

Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, China

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Hui Zeng MD,

Hui Zeng MD

Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China

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First published: 05 May 2015

https://doi.org/10.1002/ajim.22470

Citations: 19

Disclosure Statement: The authors report no conflicts of interests.

Author Contributions Statement: All the authors made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work; and drafting the work or revising it critically for important intellectual content; and final approval of the version to be published; and agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Co-first authors: Weixian Xu and Baoxia Chen

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Abstract

Background

Chronic inflammation may play an important role in linking job stress to atherosclerosis. We sought to investigate the relationship between job stress and high-sensitivity C-reactive protein (hs-CRP) among Chinese workers.

Methods

A total of 731 subjects (506 men and 225 women) were analyzed. Job stress was evaluated by effort-reward imbalance (ERI) model.

Results

Among men, after adjustment for confounders, effort, overcommitment, and ERI were significantly positively correlated with hs-CRP; and reward was significantly inversely related with hs-CRP; high level of effort, overcommitment, or ERI, respectively, significantly increased the odds of high hs-CRP with ORs of 2.0, 3.5, and 3.3 (all P < 0.001), compared with the corresponding low level groups. Among women, high overcommitment or ERI also increased risk of high hs-CRP with ORs of 2.8, and 4.1 (P < 0.05).

Conclusions

High effort, overcommmitment, and ERI were positively associated with hs-CRP. Inflammation indicated by hs-CRP may be one of important mediators linking job stress and atherosclerosis. Am. J. Ind. Med. 58:773–779, 2015. © 2015 Wiley Periodicals, Inc.

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Volume58, Issue7

July 2015

Pages 773-779

High-sensitivity CRP: Possible link between job stress and atherosclerosis

Abstract

Background

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

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High-sensitivity CRP: Possible link between job stress and atherosclerosis

Abstract

Background

Methods

Results

Conclusions

REFERENCES

Citing Literature

References

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