Plasma fibrinogen: A possible link between job stress and cardiovascular disease among Chinese workers
Weixian Xu MD, PhD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Search for more papers by this authorJuan Hang MD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorLijun Guo MD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Search for more papers by this authorYiming Zhao PhD
Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, China
Search for more papers by this authorZhaoping Li MD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Search for more papers by this authorCorresponding Author
Wei Gao MD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Department of Cardiology, Peking University Third Hospital, No 49 North Garden Road, Haidian District, Beijing 100191, China.Search for more papers by this authorWeixian Xu MD, PhD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Search for more papers by this authorJuan Hang MD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Department of Geriatrics, Peking University Shenzhen Hospital, Shenzhen, China
Search for more papers by this authorLijun Guo MD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Search for more papers by this authorYiming Zhao PhD
Research Center of Occupational Medicine, Peking University Third Hospital, Beijing, China
Search for more papers by this authorZhaoping Li MD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Search for more papers by this authorCorresponding Author
Wei Gao MD
Department of Cardiology, Peking University Third Hospital and Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing, China
Department of Cardiology, Peking University Third Hospital, No 49 North Garden Road, Haidian District, Beijing 100191, China.Search for more papers by this authorAbstract
Background
Little is known about the effect of effort–reward imbalance (ERI) on fibrinogen. We aimed to examine the association between ERI and fibrinogen among Chinese workers.
Methods
A total of 732 subjects without vascular diseases were analyzed. Associations between job stress evaluated by ERI model and plasma fibrinogen were explored by multiple regression.
Results
Effort, overcommitment, and ERI were significantly positively associated with fibrinogen, while reward was negatively related with fibrinogen both for men and for women. Compared with low level group, high level of effort, overcommitment, and ERI significantly increased risk of elevated fibrinogen (more than mean concentration) with adjusted OR of 3.3, 12.5, and 7.7 for men; 2.9, 7.2, and 7.2 for women, respectively; however, high reward reduced 80% risk for elevated fibrinogen.
Conclusions
Effort, overcommitment, and ERI are significantly associated with fibrinogen among Chinese workers. High fibrinogen may be a possible link between job stress and cardiovascular disease. Am. J. Ind. Med. 55:167–175, 2012. © 2011 Wiley Periodicals, Inc.
REFERENCES
- Aboa-Eboule C, Brisson C, Maunsell E, Masse B, Bourbonnais R, Vezina M, Milot A, Theroux P, Dagenais GR. 2007. Job strain and risk of acute recurrent coronary heart disease events. JAMA 298: 1652–1660.
- Bierhaus A, Humpert PM, Nawroth PP. 2006. Linking stress to inflammation. Anesthesiol Clin 24: 325–340.
- Clays E, De Bacquer D, Delanghe J, Kittel F, Van Renterghem L, De Backer G. 2005. Associations between dimensions of job stress and biomarkers of inflammation and infection. J Occup Environ Med 47: 878–883.
- Danesh J, Lewington S, Thompson SG, Lowe GD, Collins R, Kostis JB, Wilson AC, Folsom AR, Wu K, Benderly M, Goldbourt U, Willeit J, Kiechl S, Yarnell JW, Sweetnam PM, Elwood PC, Cushman M, Psaty BM, Tracy RP, Tybjaerg-Hansen A, Haverkate F, de Maat MP, Fowkes FG, Lee AJ, Smith FB, Salomaa V, Harald K, Rasi R, Vahtera E, Jousilahti P, Pekkanen J, D'Agostino R, Kannel WB, Wilson PW, Tofler G, Arocha-Pinango CL, Rodriguez-Larralde A, Nagy E, Mijares M, Espinosa R, Rodriquez-Roa E, Ryder E, Diez-Ewald MP, Campos G, Fernandez V, Torres E, Marchioli R, Valagussa F, Rosengren A, Wilhelmsen L, Lappas G, Eriksson H, Cremer P, Nagel D, Curb JD, Rodriguez B, Yano K, Salonen JT, Nyyssonen K, Tuomainen TP, Hedblad B, Lind P, Loewel H, Koenig W, Meade TW, Cooper JA, De Stavola B, Knottenbelt C, Miller GJ, Bauer KA, Rosenberg RD, Sato S, Kitamura A, Naito Y, Palosuo T, Ducimetiere P, Amouyel P, Arveiler D, Evans AE, Ferrieres J, Juhan-Vague I, Bingham A, Schulte H, Assmann G, Cantin B, Lamarche B, Despres JP, Dagenais GR, Tunstall-Pedoe H, Woodward M, Ben-Shlomo Y, Davey Smith G, Palmieri V, Yeh JL, Rudnicka A, Ridker P, Rodeghiero F, Tosetto A, Shepherd J, Ford I, Robertson M, Brunner E, Shipley M, Feskens EJ, Kromhout D, Dickinson A, Ireland B, Juzwishin K, Kaptoge S, Memon A, Sarwar N, Walker M, Wheeler J, White I, Wood A. 2005. Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: An individual participant meta-analysis. JAMA 294: 1799–1809.
- De Luca G, Verdoia M, Cassetti E, Schaffer A, Cavallino C, Bolzani V, Marino P. 2010. High fibrinogen level is an independent predictor of presence and extent of coronary artery disease among Italian population. J Thromb Thrombolysis 31: 458–463.
- Eller NH, Netterstrom B, Gyntelberg F, Kristensen TS, Nielsen F, Steptoe A, Theorell T. 2009. Work-related psychosocial factors and the development of ischemic heart disease: A systematic review. Cardiol Rev 17: 83–97.
- Franke WD, Kohut ML, Russell DW, Yoo HL, Ekkekakis P, Ramey SP. 2010. Is job-related stress the link between cardiovascular disease and the law enforcement profession? J Occup Environ Med 52: 561–565.
- Hamer M, Stamatakis E. 2008. Inflammation as an intermediate pathway in the association between psychosocial stress and obesity. Physiol Behav 94: 536–539.
- Hemingway H, Marmot M. 1999. Evidence based cardiology: Psychosocial factors in the aetiology and prognosis of coronary heart disease. Systematic review of prospective cohort studies BMJ 318: 1460–1467.
- Hirokawa K, Tsutsumi A, Kayaba K. 2008. Psychosocial job characteristics and plasma fibrinogen in Japanese male and female workers: The Jichi Medical School cohort study. Atherosclerosis 198: 468–476.
- Irie M, Tsutsumi A, Shioji I, Kobayashi F. 2004. Effort-reward imbalance and physical health among Japanese workers in a recently downsized corporation. Int Arch Occup Environ Health 77: 409–417.
- Ishizaki M, Martikainen P, Nakagawa H, Marmot M. 2001. Socioeconomic status, workplace characteristics and plasma fibrinogen level of Japanese male employees. Scand J Work Environ Health 27: 287–291.
- Karasek RA. 1979. Job demands, job decision latitude, and mental strain: Implications for job redesign. Admin Sci Q 24: 285–308.
- Kittel F, Leynen F, Stam M, Dramaix M, de Smet P, Mak R, De Backer G, Kornitzer M. 2002. Job conditions and fibrinogen in 14226 Belgian workers: The Belstress study. Eur Heart J 23: 1841–1848.
- Laszlo KD, Ahnve S, Hallqvist J, Ahlbom A, Janszky I. 2010. Job strain predicts recurrent events after a first acute myocardial infarction: The Stockholm Heart Epidemiology Program. J Intern Med 267: 599–611.
- Lee S, Colditz GA, Berkman LF, Kawachi I. 2003. Caregiving and risk of coronary heart disease in U.S. women: A prospective study. Am J Prev Med 24: 113–119.
- Li J, Yang W, Cheng Y, Siegrist J, Cho SI. 2005. Effort-reward imbalance at work and job dissatisfaction in Chinese healthcare workers: A validation study. Int Arch Occup Environ Health 78: 198–204.
- Li J, Yang W, Cho SI. 2006. Gender differences in job strain, effort-reward imbalance, and health functioning among Chinese physicians. Soc Sci Med 62: 1066–1077.
- Maple-Brown LJ, Cunningham J, Nandi N, Hodge A, O'Dea K. 2010. Fibrinogen and associated risk factors in a high-risk population: Urban Indigenous Australians, the DRUID Study. Cardiovasc Diabetol 9: 69.
- Ostry AS, Hershler R, Chen L, Hertzman C. 2004. A longitudinal study comparing the effort-reward imbalance and demand-control models using objective measures of physician utilization. Scand J Public Health 32: 456–463.
- Riese H, Van Doornen LJ, Houtman IL, De Geus EJ. 2000. Job strain and risk indicators for cardiovascular disease in young female nurses. Health Psychol 19: 429–440.
- Shi Y, Wu Y, Bian C, Zhang W, Yang J, Xu G. 2010. Predictive value of plasma fibrinogen levels in patients admitted for acute coronary syndrome. Tex Heart Inst J 37: 178–183.
- Siegrist J. 1996. Adverse health effects of high-effort/low-reward conditions. J Occup Health Psychol 1: 27–41.
- Siegrist J. 2010. Effort-reward imbalance at work and cardiovascular diseases. Int J Occup Med Environ Health 23: 279–285.
- Strike PC, Steptoe A. 2004. Psychosocial factors in the development of coronary artery disease. Prog Cardiovasc Dis 46: 337–347.
- Theorell T. 2002. Job stress and fibrinogen. Eur Heart J 23: 1799–1801.
- Theorell T, Karasek RA. 1996. Current issues relating to psychosocial job strain and cardiovascular disease research. J Occup Health Psychol 1: 9–26.
- Tsutsumi A, Theorell T, Hallqvist J, Reuterwall C, de Faire U. 1999. Association between job characteristics and plasma fibrinogen in a normal working population: A cross sectional analysis in referents of the SHEEP Study. Stockholm Heart Epidemiology Program. J Epidemiol Community Health 53: 348–354.
- van Vegchel N, de Jonge J, Bosma H, Schaufeli W. 2005. Reviewing the effort-reward imbalance model: Drawing up the balance of 45 empirical studies. Soc Sci Med 60: 1117–1131.
- Vrijkotte TG, van Doornen LJ, de Geus EJ. 1999. Work stress and metabolic and hemostatic risk factors. Psychosom Med 61: 796–805.
- Xu W, Zhao Y, Guo L, Guo Y, Gao W. 2009. Job stress and coronary heart disease: A case-control study using a Chinese population. J Occup Health 51: 107–113.
- Xu W, Hang J, Cao T, Shi R, Zeng W, Deng Y, Gao W, Zhao Y, Guo L. 2010a. Job stress and carotid intima-media thickness in Chinese workers. J Occup Health 52: 257–262.
- Xu W, Zhao Y, Guo L, Guo Y, Gao W. 2010b. The association between effort-reward imbalance and coronary atherosclerosis in a Chinese sample. Am J Ind Med 53: 655–661.
