Paroxysmal nocturnal hemoglobinuria terminating in TdT-positive acute leukemia
Corresponding Author
Jun'Ichi Katahira MD
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical Coliege, 10 Ichigaya-Kawadacho, Shinjuku-ku, Tokyo, JapanSearch for more papers by this authorMasako Aoyama
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan
Search for more papers by this authorKazuo Oshimi
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan
Search for more papers by this authorHideaki Mizoguchi
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan
Search for more papers by this authorMichiko Okada
Department of Anatomy, Tokyo Women's Medical College, Tokyo, Japan
Search for more papers by this authorCorresponding Author
Jun'Ichi Katahira MD
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical Coliege, 10 Ichigaya-Kawadacho, Shinjuku-ku, Tokyo, JapanSearch for more papers by this authorMasako Aoyama
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan
Search for more papers by this authorKazuo Oshimi
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan
Search for more papers by this authorHideaki Mizoguchi
Division of Hematology, Department of Internal Medicine, Tokyo Women's Medical College, Tokyo, Japan
Search for more papers by this authorMichiko Okada
Department of Anatomy, Tokyo Women's Medical College, Tokyo, Japan
Search for more papers by this authorAbstract
A case of paroxysmal nocturnal hemoglobinuria (PNH) which developed terminal transfer-ase (TdT)-positive leukemia 5 years after the diagnosis of PNH was studied. Most of the leu-kemic cells were suggestively lymphoid by cytochemistry and electron microscopy, and TdT-positive by immunofluorescence studies. The development of acute lymphoblastic leukemia during the course of PNH suggests that in PNH the clonal abnormality may involve lymphoid cells as well as myeloid cells, thus raising the possibility of the disease being a disorder of the pluripotential stem cell.
References
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