Volume 81, Issue 5 pp. 370-373
Brief Report
Free Access

Donor cell leukemia in a patient developing 11 months after an allogeneic bone marrow transplantation for chronic myeloid leukemia

Selmin Ataergin

Selmin Ataergin

Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey

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Fikret Arpaci

Corresponding Author

Fikret Arpaci

Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey

Gulhane Faculty of Medecine, Department of Medical Oncology and BMT Unit, 06010 Etlik, Ankara, TurkeySearch for more papers by this author
Turker Cetin

Turker Cetin

Department of Hematology, Gulhane Faculty of Medicine, Ankara, Turkey

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Sefik Guran

Sefik Guran

Department of Molecular Biology, Gulhane Faculty of Medicine, Ankara, Turkey

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Cengiz Yakicier

Cengiz Yakicier

Department of Molecular Biology, Gulhane Faculty of Medicine, Ankara, Turkey

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Murat Beyzadeoglu

Murat Beyzadeoglu

Department of Radiation Oncology, Gulhane Faculty of Medicine, Ankara, Turkey

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Ahmet Ozet

Ahmet Ozet

Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey

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First published: 20 April 2006
Citations: 12

Abstract

A 38-year-old female with chronic myeloid leukemia underwent an allogeneic bone marrow transplantation from her full-matched brother. Eleven months later, she readmitted with an acute leukemia that was shown to be of donor origin. The patient never achieved a remission even after chemotherapies with cytarabine and mitoxantrone, donor lymphocyte infusion, and second allogeneic peripheral blood stem cell transplantation. Donor cell leukemia (DCL) is sometimes misdiagnosed as relapse by clinicians and the real incidence may be higher than expected. Cytogenetic and molecular techniques may be helpful to clarify the issue of the leukemia. The current case is another case of DCL reported in the literature after an allogeneic transplant for a kind of leukemia. Am. J. Hematol. 81:370–373, 2006

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