Donor cell leukemia in a patient developing 11 months after an allogeneic bone marrow transplantation for chronic myeloid leukemia
Selmin Ataergin
Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorCorresponding Author
Fikret Arpaci
Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey
Gulhane Faculty of Medecine, Department of Medical Oncology and BMT Unit, 06010 Etlik, Ankara, TurkeySearch for more papers by this authorTurker Cetin
Department of Hematology, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorSefik Guran
Department of Molecular Biology, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorCengiz Yakicier
Department of Molecular Biology, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorMurat Beyzadeoglu
Department of Radiation Oncology, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorAhmet Ozet
Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorSelmin Ataergin
Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorCorresponding Author
Fikret Arpaci
Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey
Gulhane Faculty of Medecine, Department of Medical Oncology and BMT Unit, 06010 Etlik, Ankara, TurkeySearch for more papers by this authorTurker Cetin
Department of Hematology, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorSefik Guran
Department of Molecular Biology, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorCengiz Yakicier
Department of Molecular Biology, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorMurat Beyzadeoglu
Department of Radiation Oncology, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorAhmet Ozet
Department of Medical Oncology and Bone Marrow Transplantation Unit, Gulhane Faculty of Medicine, Ankara, Turkey
Search for more papers by this authorAbstract
A 38-year-old female with chronic myeloid leukemia underwent an allogeneic bone marrow transplantation from her full-matched brother. Eleven months later, she readmitted with an acute leukemia that was shown to be of donor origin. The patient never achieved a remission even after chemotherapies with cytarabine and mitoxantrone, donor lymphocyte infusion, and second allogeneic peripheral blood stem cell transplantation. Donor cell leukemia (DCL) is sometimes misdiagnosed as relapse by clinicians and the real incidence may be higher than expected. Cytogenetic and molecular techniques may be helpful to clarify the issue of the leukemia. The current case is another case of DCL reported in the literature after an allogeneic transplant for a kind of leukemia. Am. J. Hematol. 81:370–373, 2006
References
- 1 Boyd CN, Ramberg RC, Thomas ED. The incidence of recurrence of leukemia in donor cells after allogeneic bone marrow transplantation. Leuk Res 1982; 6(6): 833–837.
- 2 Hertenstein B, Hambach L, Bacigalupo A, et al. Chronic Leukaemia Working Party of the European Group for Blood and Marrow Transplantation. Development of leukemia in donor cells after allogeneic stem cell transplantation—a survey of the European Group for Blood and Marrow Transplantation (EBMT) Haematologica 2005; 90: 969–975.
- 3 Niederwieser DW, Appelbaum FR, Gastl G, Gersdorf E, Meister B, Geissler D, Tratkiewicz JA, Thaler J, Huber C. Inadvertent transmission of a donor's acute myeloid leukemia in bone marrow transplantation for chronic myelocytic leukemia. N Engl J Med 1990; 322(25): 1794–1796.
- 4 Thomas ED, Bryant JI, Buckner CD, Clift RA, Fefer A, Neiman P, Ramberg RE, Storb R. Leukemic transformation of engrafted human marrow. Transplant Proc 1972; 4(4): 567–570.
- 5 Cransac M, Boiron JM, Merel P, Cony-Makhoul P, Marit G, Bernard P, Ferrer J, Reiffers J. Burkitt-type acute lymphoblastic leukemia in donor cells after allogeneic bone marrow transplantation for acute nonlymphoblastic leukemia. Transplantation 1993; 56(1): 120.
- 6 Fialkow PJ, Thomas ED, Bryant JI, Neiman PE. Smith JL, Heerema NA, Provisor AJ. Leukaemic transformation of engrafted human marrow cells in vivo. Leukaemic transformation of engrafted bone marrow cells. Lancet 1971; 1(7693): 251–255.
- 7 Smith JL, Heerema NA, Provisor AJ. Leukaemic transformation of engrafted bone marrow cells. Br J Haematol 1985; 60(3): 415–422.
- 8 Stein J, Zimmerman PA, Kochera M, et al. Origin of leukemic relapse after bone marrow transplantation: comparison of cytogenetic and molecular analyses. Blood 1989; 73: 2033–2040.
- 9 Lawler SD, Baker MC, Harris H, Morgenstern GR. Cytogenetic studies on recipients of allogeneic bone marrow using the sex chromosomes as markers of cellular origin. Br J Haematol 1984; 56: 431–443.
- 10 Marmont A, Frassoni F, Bacigalupo A, Podesta M, Piaggio G, Van Lint MT, Caimo A, de Filippi S. Recurrence of Ph'-positive leukemia in donor cells after marrow transplantation for chronic granulocytic leukemia. N Engl J Med 1984; 310(14): 903–906.
- 11 Schmitz N, Johannson W, Schmidt G, von der Helm K, Loffler H. Recurrence of acute lymphoblastic leukemia in donor cells after allogeneic marrow transplantation associated with a deletion of the long arm of chromosome 6. Blood 1987; 70(4): 1099–10104.
- 12 Naoe T, Kiyoi H, Yamanaka K, Naito K, Yamada K. A case of cALL relapse after allogeneic BMT: recurrence of recipient cell origin, initially determined as being that of donor cell origin by sex chromosome analysis. Br J Haematol 1989; 73(3): 420–422.
- 13 Stein J, Zimmerman PA, Kochera M, Strandjord S, Golden W, Simon M, Warkentin P, Blazar BR, Coccia P, Lang-Unnasch N. Origin of leukemic relapse after bone marrow transplantation: comparison of cytogenetic and molecular analyses. Blood 1989; 73(7): 2033–2040.
- 14 Mouratidou M, Sotiropoulos D, Deremitzaki K, Spathas DH, Hoffbrand AV, Prentice HG, Papanastasiou K, Tsakanikas S, Tsaftaridis P, Stamatelou M, et al. Recurrence of acute leukemia in donor cells after bone marrow transplantation: documentation by in situ DNA hybridization. Bone Marrow Transplant 1993; 12(1): 77–80.
- 15 Abeliovich D, Yehuda O, Nagler A, Lerer I, Ben-Neriah S, Amar A, Or R. Predominant 45,X,--Y karyotype in donor cells after allogeneic BMT: cytogenetic and molecular analysis. Cancer Genet Cytogenet 1996; 86(1): 1–7.
- 16 Saito Y, Uzuka Y, Sakai N, Suzuki S, Toyota T. A Philadelphia chromosome positive acute lymphoblastic leukemia of donor origin after allogeneic bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Bone Marrow Transplant 2000; 25(11): 1209–1211.
- 17
Cooley LD,
Sears DA,
Udden MM,
Harrison WR,
Baker KR,
Donor cell leukemia: report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature.
Am J Hematol
2000;
63(1):
46–53.
10.1002/(SICI)1096-8652(200001)63:1<46::AID-AJH11>3.0.CO;2-F CAS PubMed Web of Science® Google Scholar
- 18 Hambach L, Eder M, Dammann E, Battmer K, Stucki A, Heil G, Ganser A, Hertenstein B. Donor cell-derived acute myeloid leukemia developing 14 months after matched unrelated bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplant 2001; 28(7): 705–707.
- 19 Au WY, Chan EC, Siu LL, Lau TC, Lie AK, Ma SK, Kwong YL. Leukaemic relapse of donor origin after allogeneic bone marrow transplantation from a donor who later developed bronchogenic carcinoma. Br J Haematol 2002; 119(3): 777–780.
- 20 Gopcsa L, Barta A, Banyai A, Konya M, Pajor L, Foldi J, Paloczi K. Acute myeloid leukaemia of donor cell origin developing 5 years after allogeneic bone marrow transplantation for chronic myeloid leukaemia. Bone Marrow Transplant 2002; 29(5): 449–452.
- 21 Au WY, Lam CC, Lie AK, Pang A, Kwong YL. T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation. Am J Clin Pathol 2003; 120(4): 626–630.
- 22 Daly AS, Kamel-Reid S, Lipton JH, Messner HA, Kiss TL, Chun K, Busque L, Chang H. Acute leukemia of donor origin arising after stem cell transplantation for acute promyelocytic leukemia Leuk Res 2004; 28(10): 1107–1111.
- 23 Chang H, Kamel-Reid S, Hussain N, Lipton J, Messner HA. T-cell large granular lymphocytic leukemia of donor origin occurring after allogeneic bone marrow transplantation for B-cell lymphoproliferative disorders. Am J Clin Pathol 2005; 123(2): 196–199.