In the last few decades, renewable energy sources have become a good approach for the generation of energy sources without affecting any kind of pollution in the earth's atmosphere, in which the solar cell has become the best choice for an energy harvesting tool in the last few decades. Nowadays, conventional solar cells are fabricated using p–n junction-type semiconductors that are used for the manufacturing of solar panels. For the conventional solar cell, silicon-based materials are most commonly used in solar panels. But these pristine materials are not sufficient enough to produce the power conversion efficiency (PCE) in solar cells. Conventional solar cells have disadvantages in PCE, high manufacturing cost, low electron/ion transfer rate, high reflection of sunlight, and low photon absorption, making them less efficient for the generation of renewable energy sources. Recently, nanostructured-based materials have been researched and developed for the advanced management of photon absorption in thin films for solar cells. In which, 1D semiconductor nanowire materials have attracted a lot of attention for solar cells to improve PCE, cheaper, high electron/ion transfer, low refection, high photon absorption, etc. Semiconducting nanowire-based hybrid structures are most suitable for soar cells because they have a higher surface-to-volume ratio, lower dimensions, as well as a shorter diffusion length. This chapter emphasized the use of semiconducting nanowire hybrid structures for solar cells, including how they were made, how they were used, and how they were compared to other types of solar cells in terms of their PCE.