Chapter 12
3D Printing of Metallic Cellular Scaffolds for Bone Implants
Xipeng Tan,
Yu Jun Tan,
Xipeng Tan
Nanyang Technology University, Singapore Centre for 3D Printing, 50 Nanyang Avenue, 639798 Singapore
Search for more papers by this authorYu Jun Tan
National University of Singapore, Biomedical Institute for Global Health Research and Technology, 21 Lower Kent Ridge Road, 119077 Singapore
Search for more papers by this authorXipeng Tan,
Yu Jun Tan,
Xipeng Tan
Nanyang Technology University, Singapore Centre for 3D Printing, 50 Nanyang Avenue, 639798 Singapore
Search for more papers by this authorYu Jun Tan
National University of Singapore, Biomedical Institute for Global Health Research and Technology, 21 Lower Kent Ridge Road, 119077 Singapore
Search for more papers by this authorBook Editor(s):Mohammed Maniruzzaman,
Mohammed Maniruzzaman
School of Life Sciences, University of Sussex, Brighton, UK, BN1 9QG
Search for more papers by this authorSummary
This chapter introduces the emerging powder bed fusion (PBF) 3D printing techniques for producing metallic cellular scaffolds for bone implants as well as the available metallic biomaterials. It reviews the recent advances in 3D printing of metallic cellular scaffolds with various unit cell topologies in detail. The chapter mainly focuses on the newly developed 3D printing technology and its applications in cellular scaffolds using a variety of metallic biomaterials. Selective laser melting (SLM) and selective electron beam melting (SEBM) are the representative PBF 3D printing techniques for metals and alloys nowadays. There are two types of cellular solids, namely, the closed and open cellular structures. Cellular structures can be divided into two main groups in terms of unit cell form, i.e. the stochastic structure and the reticulated structure. 3D printing has shown to be able to fabricate most of the biometals into cellular scaffolds for implants.
References
- Yang, S., Leong, K.-F., Du, Z., and Chua, C.-K. (2001). The design of scaffolds for use in tissue engineering. Part I. traditional factors. Tissue Engineering 7 (6): 679–689.
-
Yusop, A.H., Bakir, A.A., Shaharom, N.A. et al. (2012). Porous biodegradable metals for hard tissue scaffolds: a review.
International Journal of Biomaterials
2012: 1–10.
10.1155/2012/641430 Google Scholar
- Chen, Q. and Thouas, G.A. (2015). Metallic implant biomaterials. Materials Science and Engineering R Reports 87: 1–57.
- Research and Markets (2017). Global Bone Graft and Substitutes Market Analysis & Trends – Industry Forecast to 2025.
- Amini, A.R., Laurencin, C.T., and Nukavarapu, S.P. (2012). Bone tissue engineering: recent advances and challenges. Critical Reviews in Biomedical Engineering 40 (5): 363–408.
- Melancon, D., Bagheri, Z.S., Johnston, R.B. et al. (2017). Mechanical characterization of structurally porous biomaterials built via additive manufacturing: experiments, predictive models, and design maps for load-bearing bone replacement implants. Acta Biomaterialia 63: 350–368.
- Tan, X.P., Tan, Y.J., Chow, C.S.L. et al. (2017). Metallic powder-bed based 3D printing of cellular scaffolds for orthopaedic implants: a state-of-the-art review on manufacturing, topological design, mechanical properties, and biocompatibility. Materials Science and Engineering C 76: 1328–1343.
- Kok, Y., Tan, X.P., Wang, P. et al. (2018). Anisotropy and heterogeneity of microstructure and mechanical properties in metal additive manufacturing: a critical review. Materials and Design 139: 565–586.
- Sing, S.L., An, J., Yeong, W.Y., and Wiria, F.E. (2016). Laser and electron-beam powder-bed additive manufacturing of metallic implants: a review on processes, materials and designs. Journal of Orthopaedic Research 34 (3): 369–385.
- Sun, Z., Tan, X.P., Tor, S.B., and Yeong, W.Y. (2016). Selective laser melting of stainless steel 316L with low porosity and high build rates. Materials and Design 104: 197–204.
- Tan, X.P., Kok, Y., Tan, Y.J. et al. (2015). Graded microstructure and mechanical properties of additive manufactured Ti-6Al-4V via electron beam melting. Acta Materialia 97: 1–16.
-
Prasad, K., Bazaka, O., Chua, M. et al. (2017). Metallic biomaterials: current challenges and opportunities.
Materials (Basel)
10 (8): 884.
10.3390/ma10080884 Google Scholar
- Wang, X., Xu, S., Zhou, S. et al. (2016). Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: a review. Biomaterials 83: 127–141.
- Agarwal, S., Curtin, J., Duffy, B., and Jaiswal, S. (2016). Biodegradable magnesium alloys for orthopaedic applications: a review on corrosion, biocompatibility and surface modifications. Materials Science and Engineering C 68: 948–963.
- Hermawan, H. (2012). Biodegradable metals: state of the art. In: Biodegradable Metals, SpringerBriefs in Materials. Berlin, Heidelberg: Springer-Verlag.
- Long, M. and Rack, H.J. (1998). Titanium alloys in total joint replacement – a materials science perspective. Biomaterials 19 (18): 1621–1639.
-
Murphy, W., Black, J., and Hastings, G. (2016). Handbook of Biomaterial Properties, 2e. Springer.
10.1007/978-1-4939-3305-1 Google Scholar
- Biesiekierski, A., Wang, J., Abdel-Hady Gepreel, M., and Wen, C. (2012). A new look at biomedical Ti-based shape memory alloys. Acta Biomaterialia 8 (5): 1661–1669.
- Tan, X.P., Kok, Y., Toh, W.Q. et al. (2016). Revealing martensitic transformation and α/β interface evolution in electron beam melting three-dimensional-printed Ti-6Al-4V. Scientific Reports 6 (26039): 1–10.
-
Tan, X.P., Wang, P., Kok, Y. et al. (2018). Carbide precipitation characteristics in additive manufacturing of Co-Cr-Mo alloy via selective election beam melting.
Scripta Materialia
143: 117–121.
10.1016/j.scriptamat.2017.09.022 Google Scholar
- Van Hooreweder, B., Lietaert, K., Neirinck, B. et al. (2017). CoCr F75 scaffolds produced by additive manufacturing: influence of chemical etching on powder removal and mechanical performance. Journal of the Mechanical Behavior of Biomedical Materials 70: 60–67.
- Shah, F.A., Omar, O., Suska, F. et al. (2016). Long-term osseointegration of 3D printed CoCr constructs with an interconnected open-pore architecture prepared by electron beam melting. Acta Biomaterialia 36: 296–309.
- Wang, C.C., Tan, X.P., Liu, E., and Tor, S.B. (2018). Process parameter optimization and mechanical properties for additively manufactured stainless steel 316L parts by selective electron beam melting. Materials & Design 147: 157–166.
- Elahinia, M.H., Hashemi, M., Tabesh, M., and Bhaduri, S.B. (2012). Manufacturing and processing of NiTi implants: a review. Progress in Materials Science 57 (5): 911–946.
- Elahinia, M., Shayesteh Moghaddam, N., Taheri Andani, M. et al. (2016). Fabrication of NiTi through additive manufacturing: a review. Progress in Materials Science 83: 630–663.
- Thijs, L., Montero Sistiaga, M.L., Wauthle, R. et al. (2013). Strong morphological and crystallographic texture and resulting yield strength anisotropy in selective laser melted tantalum. Acta Materialia 61 (12): 4657–4668.
- Wauthle, R., Van Der Stok, J., Yavari, S.A. et al. (2015). Additively manufactured porous tantalum implants. Acta Biomaterialia 14: 217–225.
-
Ng, C.C., Savalani, M.M., Lau, M.L., and Man, H.C. (2011). Microstructure and mechanical properties of selective laser melted magnesium.
Applied Surface Science
257 (17): 7447–7454.
10.1016/j.apsusc.2011.03.004 Google Scholar
-
Chung Ng, C., Savalani, M., and Chung Man, H. (2011). Fabrication of magnesium using selective laser melting technique.
Rapid Prototyping Journal
17 (6): 479–490.
10.1108/13552541111184206 Google Scholar
- Taltavull, C., Torres, B., Lopez, A.J. et al. (2012). Selective laser surface melting of a magnesium–aluminium alloy. Materials Letters 85: 98–101.
- Wei, K., Gao, M., Wang, Z., and Zeng, X. (2014). Effect of energy input on formability, microstructure, and mechanical properties of selective laser melted AZ91D magnesium alloy. Materials Science and Engineering A 611: 212–222.
- Jauer, L., Meiners, W., Vervoort, S. et al. (2016). Selective laser melting of magnesium alloys. In: European Congress and Exhibition on Powder Metallurgy. European PM Conference Proceedings, 1–6. The European Powder Metallurgy Association.
- Hollister, S.J. (2005). Porous scaffold design for tissue engineering. Nature Materials 4 (July): 518–524.
- Deshpande, V.S., Ashby, M.F., and Fleck, N.A. (2001). Foam topology: bending versus stretching dominated architectures. Acta Materialia 49 (6): 1035–1040.
- Parthasarathy, J., Starly, B., Raman, S., and Christensen, A. (2010). Mechanical evaluation of porous titanium (Ti6Al4V) structures with electron beam melting (EBM). Journal of the Mechanical Behavior of Biomedical Materials 3 (3): 249–259.
- Arabnejad, S., Burnett Johnston, R., Pura, J.A. et al. (2016). High-strength porous biomaterials for bone replacement: a strategy to assess the interplay between cell morphology, mechanical properties, bone ingrowth, and manufacturing constraints. Acta Biomaterialia. 30: 345–356.
- Bragdon, C.R., Jasty, M., Greene, M. et al. (2004). Biologic fixation of total hip implants. Journal of Bone and Joint Surgery 86: 105–117.
-
Harrysson, O.L.A., Cansizoglu, O., Marcellin-Little, D.J. et al. (2008). Direct metal fabrication of titanium implants with tailored materials and mechanical properties using electron beam melting technology.
Materials Science and Engineering C
28 (3): 366–373.
10.1016/j.msec.2007.04.022 Google Scholar
- Murr, L.E., Gaytan, S.M., Medina, F. et al. (2010). Next-generation biomedical implants using additive manufacturing of complex, cellular, and functional mesh arrays. Philosophical Transactions. Series A: Mathematical, Physical and Engineering Sciences 368 (1917): 1999–2032.
- Murr, L.E., Gaytan, S.M., Medina, F. et al. (2010). Characterization of Ti-6Al-4V open cellular foams fabricated by additive manufacturing using electron beam melting. Materials Science and Engineering A 527 (7–8): 1861–1868.
-
Surmeneva, M.A., Surmenev, R.A., Chudinova, E.A. et al. (2017). Fabrication of multiple-layered gradient cellular metal scaffold via electron beam melting for segmental bone reconstruction.
Materials and Design
133: 195–204.
10.1016/j.matdes.2017.07.059 Google Scholar
